Showing 3 results for Administration
Shahram Ala, Ozra Akha, Zahra Kashi, Hosein Asgarirad, Adeleh Bahar, Neda Sasanpoor,
Volume 6, Issue 3 (7-2015)
Abstract
Background: Levothyroxine is commonly used in the treatment of
patients with hypothyroidism. Levothyroxine is often administered in the
morning, on an empty stomach, to increase its absorption. However, many
patients have trouble for taking levothyroxine in the morning. The aim of this
study was to evaluate the effect of changing administration time of
levothyroxine from before breakfast to before dinner on serum levels of TSH and
T4.
Methods: Fifty hypothyroidism patients aged 18-75 years old
were included in the study and randomly divided into two groups. Each group
received two tablets per day blindly (one
levothyroxine tablet and one placebo tablet) before breakfast and before
dinner. After two months, the administration time for the tablets was changed
for each group, and the new schedule was continued for a further two-month
period. The serum TSH and T4 levels were measured before and after treatment in
each group.
Results: Changing the levothyroxine administration time,
resulted in 1.47±0.51 µIU/mL increase in TSH level (P=0.001) and 0.35±1.05µg/dL
decrease in T4 level (P=0.3).
Conclusion: Changing the levothyroxine administration time from before
breakfast to before dinner minimally reduced the therapeutic efficacy of
levothyroxine.
Fatemeh Zahra Bagheri, Mahboobeh Azadehrah, Bizhan Shabankhani, Hooshang Akbari, Ebrahim Nasiri Ferami,
Volume 13, Issue 1 (1-2022)
Abstract
Background: Misoprostol is a myometrial stimulant with uterotonic properties and can be administered rectally, vaginally, or sublingually. Numerous studies have investigated the effect of misoprostol on the prevention and treatment of PPH (postpartum hemorrhage) after vaginal delivery, but its use to control PPH during cesarean section has not been widely studied.
Methods: In this clinical trial study, 180 pregnant women who were candidates for cesarean section were included in the study. They were divided into 3 groups of 60 people (sublingual misoprostol group, rectal misoprostol group, control group). In all three groups, the volume of blood lost was recorded in the checklist at the end of surgery. Data were entered into SPSS software and analyzed.
Results: The mean bleeding in the control group was 225.4±63.9, while it was 137.9±33.8 and 118.9±28.5 in the sublingual misoprostol group and rectal misoprostol group, respectively. We had significantly more bleeding in the control group (p<0.001) compared to the other two groups.
Conclusion: These results confirm the positive effect of misoprostol in reducing bleeding and show the superiority of using rectal misoprostol compared to other methods of reducing bleeding during cesarean section.
Arezou Hamzehzadeh Alamdari, Samira Ahrabi, Manouchehr Khoshbaten, Shahram Roustaei, Sara Araqchin Ahrabi, Mohammad Asghari Jafarabadi,
Volume 13, Issue 1 (1-2022)
Abstract
Background: Due to the interruption of the EHC pathway in NAFLD patients, we hypothesized that parenteral vitamin D supplementation is superior to oral in vitamin D insufficient patients with NAFLD. Therefore, this study aimed to compare the efficacy of oral and parenteral routes of vitamin D supplementation on serum 25(OH) vitamin D levels in patients with NAFLD.
Methods: In this prospective randomized trial, 66 NAFLD cases with vitamin D deficiency were studied. For 33 cases, oral vitamin D was supplemented, whereas the other 33 patients were given an intramuscular injection of vitamin D. Laboratory tests and liver ultrasound were performed at the beginning and the end of the trial for each subject.
Results: Regardless of the drug administration route, at the end of this trial the mean of serum 25-hydroxy vitamin D level increased from 8.74±2.47 to 33.16±17.61 (P=0.00), and the mean±SD for serum triglyceride decreased from 191.46±92.79 to 166.00±68.30 (P=0.02), both were statistically significant. Liver ultrasound reported statistically significant changes in the grade of fatty liver disease (P=0.003). In the comparison between the two groups, serum 25-hydroxy vitamin D level changes were not statistically significant (P=0.788).
Conclusion: The intramuscular method of supplementation was not better than the oral route in improving serum 25(OH) vitamin D levels in NAFLD patients. In this study, the impaired EHC and vitamin D absorption inhibitor factors in NAFLD patients did not affect the final result of serum vitamin D levels significantly.
