Non-thyroidal illness syndrome and cardiopulmonary bypass in children with congenital heart disease
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چکیده: (7696 مشاهده) |
Abstract Background: The thyroid hormones influence on all metabolic
pathways. After heart surgery using cardiopulmonary bypass (CPB), serum T3
decreases and remains low for at least 24 hours. Several studies on pediatric
have reported reduction of thyroid hormones after heart surgery. This study
aimed to investigate the status of thyroid function tests in children with CPB
surgery. Methods: This study was carried out based on the available
data on 132 children aged less than 15 years suffering from CHD. The patients
underwent open heart surgery in Rajaie Center in Iran from January to November
2010. The thyroid hormone levels were measured shortly after admission, and
postoperatively in Intensive Care Unit (ICU) and thereafter at 12, 24 and
48-hour intervals. The patients’ gender, age, weight, body mass index, heart
disease details, previous cardiac surgeries, and cardiac surgery-related data
such as pump time, aortic clamping time, hypothermia duration, postoperative
hemodynamic status and postoperative use of inotropic drugs were recorded and analyzed Results: All patients showed a
decrease in T3, T4 and TSH and an increase in T3-resin uptake after surgery.
Eventually, 3 (3.2%) patients died. Preoperatively, there was a significant
association between the reduction in the thyroid hormone levels and inotropic
drugs as well as the type of the heart disease (p<0.05). Conclusion: There is an association between post-operative
inotropic drugs administration and reduction thyroid hormones levels in
patients undergoing congenital heart disease cardiopulmonary bypass surgery. |
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نوع مطالعه: Original Article |
موضوع مقاله:
Internal دریافت: 1393/6/29 | پذیرش: 1393/6/29 | انتشار: 1393/6/29
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