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Efficacy of adding glutazone to the maximum dose of glibenclamide and metformin resistant on type 2 diabetic patients
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چکیده: (10327 مشاهده) |
Background: To evaluate the efficacy of adding the glutazone to maximum dose of sulfonylurea and metformin in patients with poorly controlled type 2 diabetes.
Methods: Ninety six patients with type 2 diabetes who had failed medical therapy with maximal-dosage of metformin and glibenclamide received glutazone. Fasting blood sugar (FBS), 2 hours postprandial (2hpp) glucose, hemoglobin A1C, cholesterol and HDL levels were assessed at baseline three months later.
Results: Ninety-six patients with type 2 diabetes (74 women and 22 men) with the mean age of 55.7±9.9 years were studied. Significant reduction was seen in fasting blood sugar (FBS), 2 hours postprandial (2hpp) glucose, hemoglobin A1C and triglyceride levels three months after adding glutazone to therapeutic regimen (p<0.0005). There was not a significant rise in cholesterol and HDL levels before and after the new therapy.
Conclusion: The results show that the combination of glutazone, metformin and glibenclamide may result in better control of glycemic status in diabetic patients resistant to oral first-line agents. |
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متن کامل [PDF 53 kb]
(2642 دریافت)
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نوع مطالعه: Original Article |
موضوع مقاله:
Infectious Diseases
دریافت: 1392/10/24 | پذیرش: 1392/10/24 | انتشار: 1392/10/24
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