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A Case Report of Breast Metastasis from Gastric Carcinoma
Elahe Safari * , Leila Kiani , Fatemeh Kiani , Maryam Kadivar , Negar Hosseinaei
Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran , safari.e@iums.ac.ir
Abstract:   (1600 Views)
Background: There are rare cases of breast metastasis from gastric carcinoma origin. In this regard, we presented a case of signet ring cell stomach cancer with metastasis to the breast.
Methods: The case was a 43-year-old female with a history of gastric cancer and chief complaint of progressive bilateral and gradual breast enlargement and mass palpation 6 years after stomach surgery. An excisional biopsy of the right breast was performed at the early phase of her clinical symptoms with the pathology at the early phase of fibroadenoma and sclerosing adenosis. Given the persistent right breast thickening and enlargement, the ultrasonography and MRI together showed right breast large masses, ductal enhancement in left retro areolar space beside bilaterally enlarged axillary lymph nodes after 6 months. In this phase, the core needle biopsy showed right breast mass adenocarcinoma consistent with metastatic gastric carcinoma and also core needle biopsy of both axillary lymph nodes indicating the involvement by tumor consistent with metastatic gastric carcinoma. In the IHC, breast tumor cells were negative for ER, PR, HER2/ neu, GATA3, GCDFP15 and CK20, but positive for CK7, CK19, and CDx2. The patient died 15 months after the diagnosis of metastasis and chemotherapy treatment.
Conclusion: The diagnosis of this rare case breast metastasis of gastric carcinoma and similar cases was confirmed according to the past history of the patient, histological finding, and immune-histological markers.
Keywords: Breast, gastric carcinoma, metastasis
Type of Study: case report | Subject: Pathology
Received: 2019/04/14 | Accepted: 2019/09/29 | Published: 2017/07/15
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Caspian Journal of Internal Medicine
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