Caspian Journal of Internal Medicine
Babol University of Medical Sciences
یکشنبه 16 دی 1403
[Archive]
دوره 13، شماره 4 - ( 7-1401 )
جلد 13 شماره 4 صفحات 804-800 |
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Ala S, Saeedi M, Ghasemi A, Namdari M, Koulaeinejad N. Effect of atorvastatin 1% mouthwash in the prevention of radiotherapy induced mucositis: A pilot study. Caspian J Intern Med 2022; 13 (4) :800-804
URL: http://caspjim.com/article-1-2805-fa.html
URL: http://caspjim.com/article-1-2805-fa.html
Effect of atorvastatin 1% mouthwash in the prevention of radiotherapy induced mucositis: A pilot study. . 1401; 13 (4) :800-804
چکیده: (2961 مشاهده)
Background: Oral mucositis is a troublesome symptom for people who receive radiotherapy and chemotherapy and it is a dose-dependent factor. Atorvastatin is a HMG-CoA reductase inhibitors and various studies have proven its anti-inflammatory effects. The goal of this study was to evaluate atorvastatin 1% mouthwash effects in prevention of radiotherapy-induced mucositis.
Methods: Atorvastatin 1% suspension was prepared for mouthwash in this randomized, double-blind clinical trial. Thirty patients randomly received atorvastatin or placebo mouthwash. They had to gargle 5cc of mouthwash, 3 times per day during radiotherapy. The severity and pain of mucositis was evaluated every week, during their treatment.
Results: The severity of mucositis between the two study groups was significant every four weeks (p<0.05) and the percentage of patients with more severe mucositis was less in the atorvastatin group. It is found that the pain intensity was lower after 3 and 4 weeks in atorvastatin group.
Conclusion: These findings indicated that atorvastatin mouthwash showed a significant activity in relieving of radiotherapy-induced oral mucositis and pain.
Methods: Atorvastatin 1% suspension was prepared for mouthwash in this randomized, double-blind clinical trial. Thirty patients randomly received atorvastatin or placebo mouthwash. They had to gargle 5cc of mouthwash, 3 times per day during radiotherapy. The severity and pain of mucositis was evaluated every week, during their treatment.
Results: The severity of mucositis between the two study groups was significant every four weeks (p<0.05) and the percentage of patients with more severe mucositis was less in the atorvastatin group. It is found that the pain intensity was lower after 3 and 4 weeks in atorvastatin group.
Conclusion: These findings indicated that atorvastatin mouthwash showed a significant activity in relieving of radiotherapy-induced oral mucositis and pain.
نوع مطالعه: Short Communication |
موضوع مقاله:
Oncology
دریافت: 1399/12/23 | پذیرش: 1400/6/27 | انتشار: 1401/6/24
دریافت: 1399/12/23 | پذیرش: 1400/6/27 | انتشار: 1401/6/24
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