[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Contact us::
Site Facilities::
Impact Factor 2022: 1.4
Cite Score 2022: 2.1
SJR 2022: 0.347
SNIP 2022: 0.545
Publication Charge
►Publication Fee
In Press
 In Press Articles
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
:: Volume 13, Issue 4 (Autumn 2022) ::
Caspian J Intern Med 2022, 13(4): 800-804 Back to browse issues page
Effect of atorvastatin 1% mouthwash in the prevention of radiotherapy induced mucositis: A pilot study
Shahram Ala , Majid Saeedi , Arash Ghasemi , Melika Namdari , Neda Koulaeinejad
Department of radiology and radiation oncology, Faculty of medicine, Mazandaran University of medical science, Sari, Iran , dr_arash_ghasemi@yahoo.com
Abstract:   (2482 Views)
Background: Oral mucositis is a troublesome symptom for people who receive radiotherapy and chemotherapy and it is a dose-dependent factor. Atorvastatin is a HMG-CoA reductase inhibitors and various studies have proven its anti-inflammatory effects. The goal of this study was to evaluate atorvastatin 1% mouthwash effects in prevention of radiotherapy-induced mucositis.
Methods: Atorvastatin 1% suspension was prepared for mouthwash in this randomized, double-blind clinical trial. Thirty patients randomly received atorvastatin or placebo mouthwash. They had to gargle 5cc of mouthwash, 3 times per day during radiotherapy. The severity and pain of mucositis was evaluated every week, during their treatment.
Results: The severity of mucositis between the two study groups was significant every four weeks (p<0.05) and the percentage of patients with more severe mucositis was less in the atorvastatin group. It is found that the pain intensity was lower after 3 and 4 weeks in atorvastatin group.
Conclusion: These findings indicated that atorvastatin mouthwash showed a significant activity in relieving of radiotherapy-induced oral mucositis and pain.
Keywords: Atorvastatin, Mouthwash, Oral mucositis, Radiotherapy
Full-Text [PDF 207 kb]   (754 Downloads)    
Type of Study: Short Communication | Subject: Oncology
Received: 2021/03/13 | Accepted: 2021/09/18 | Published: 2022/09/15
Send email to the article author

Add your comments about this article
Your username or Email:


XML     Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ala S, Saeedi M, Ghasemi A, Namdari M, Koulaeinejad N. Effect of atorvastatin 1% mouthwash in the prevention of radiotherapy induced mucositis: A pilot study. Caspian J Intern Med 2022; 13 (4) :800-804
URL: http://caspjim.com/article-1-2805-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 13, Issue 4 (Autumn 2022) Back to browse issues page
Caspian Journal of Internal Medicine
Persian site map - English site map - Created in 0.05 seconds with 40 queries by YEKTAWEB 4642