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Effect of atorvastatin 1% mouthwash in the prevention of radiotherapy induced mucositis: A pilot study
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Shahram Ala    , Majid Saeedi , Arash Ghasemi , Melika Namdari , Neda Koulaeinejad |
| Department of radiology and radiation oncology, Faculty of medicine, Mazandaran University of medical science, Sari, Iran , dr_arash_ghasemi@yahoo.com |
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Abstract: (2545 Views) |
Background: Oral mucositis is a troublesome symptom for people who receive radiotherapy and chemotherapy and it is a dose-dependent factor. Atorvastatin is a HMG-CoA reductase inhibitors and various studies have proven its anti-inflammatory effects. The goal of this study was to evaluate atorvastatin 1% mouthwash effects in prevention of radiotherapy-induced mucositis.
Methods: Atorvastatin 1% suspension was prepared for mouthwash in this randomized, double-blind clinical trial. Thirty patients randomly received atorvastatin or placebo mouthwash. They had to gargle 5cc of mouthwash, 3 times per day during radiotherapy. The severity and pain of mucositis was evaluated every week, during their treatment.
Results: The severity of mucositis between the two study groups was significant every four weeks (p<0.05) and the percentage of patients with more severe mucositis was less in the atorvastatin group. It is found that the pain intensity was lower after 3 and 4 weeks in atorvastatin group.
Conclusion: These findings indicated that atorvastatin mouthwash showed a significant activity in relieving of radiotherapy-induced oral mucositis and pain. |
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| Keywords: Atorvastatin, Mouthwash, Oral mucositis, Radiotherapy |
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Full-Text [PDF 207 kb]
(769 Downloads)
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Type of Study: Short Communication |
Subject:
Oncology
Received: 2021/03/13 | Accepted: 2021/09/18 | Published: 2022/09/15
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