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:: Volume 8, Issue 2 (2-2017) ::
Caspian J Intern Med 2017, 8(2): 91-98 Back to browse issues page
Does adjuvant chemotherapy change bone mineral density and related serum biomarkers in women with breast cancer?
Reza Safaei-Nodehi *, Javad Esmaili, Ramazanali Sharifian, Shafieh Movaseghi, Sayeh Parkhideh
Hematology- Oncology and BMT center, Tehran University of medical sciences, Tehran, Iran. , safaei@gmail.com
Abstract:   (6578 Views)

Background: The primary objective of this study was to assess BMD change in Iranian females with breast cancer.

Methods: A sample of 73 female breast cancer patients treated with adjuvant chemotherapy either alone or followed by radiotherapy between March 2013 and February 2016 were considered for this study. Bone mineral density (BMD) change was evaluated by measuring z-score of lumbar spine, femoral neck (right and left side) as well as biochemical measurements. With respect to WHO categorization for the treatment of osteoporosis, patients were categorized as normal BMD, osteopenic and all analysis was done separately.

Results: In women with normal BMD, lumbar spine and femoral neck (right side) z-score decreased significantly by 15.7 and 39%, respectively (p<0.05). In osteoporosis group, there was no BMD change in any of the lumbar or femoral neck z-scores. However, in osteopenic patients, femoral neck BMD decreased significantly by 40.9% after 8 months (p=0.003). The level of all measured biomedical markers such as Ca, Alb, P and vitamin OHD decreased significantly in a follow-up visit in both osteoporosis and normal BMD.

Conclusion: Our results revealed that adjuvant chemotherapy led to unfavorable effects on lumbar spine and femoral neck means z-score during 8 months. Also, unfavorable changes in biochemical markers appeared in all groups.

Keywords: bone mineral density, breast cancer, chemotherapy, Z-score
Full-Text [PDF 497 kb]   (1609 Downloads)    
Type of Study: Original Article | Subject: Oncology
Received: 2016/07/20 | Accepted: 2016/11/27 | Published: 2017/02/20
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Safaei-Nodehi R, Esmaili J, Sharifian R, Movaseghi S, Parkhideh S. Does adjuvant chemotherapy change bone mineral density and related serum biomarkers in women with breast cancer? . Caspian J Intern Med. 2017; 8 (2) :91-98
URL: http://caspjim.com/article-1-821-en.html


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Volume 8, Issue 2 (2-2017) Back to browse issues page
Caspian Journal of Internal Medicine
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