Caspian Journal of Internal Medicine
Babol University of Medical Sciences
Thu, Mar 20, 2025
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Volume 2, Issue 2 (1-2011)
Caspian J Intern Med 2011, 2(2): 213-217 |
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Mohammad Reza S, Sarzare F, Merat F, Salehifar E, Moghadamnia A A, Hashemi Soteh S M B. Metabolic capacity of CYP2D6 within an Iranian population (Mazandaran Province). Caspian J Intern Med 2011; 2 (2) :213-217
URL: http://caspjim.com/article-1-104-en.html
URL: http://caspjim.com/article-1-104-en.html
Shiran Mohammad Reza * 
, Fatemeh Sarzare , Fatemeh Merat , Ebrahim Salehifar , Ali Akbar Moghadamnia , Seyed Mohammad Bagher Hashemi Soteh
, Fatemeh Sarzare , Fatemeh Merat , Ebrahim Salehifar , Ali Akbar Moghadamnia , Seyed Mohammad Bagher Hashemi Soteh
Abstract: (9217 Views)
Background: CYP2D6 is polymorphically expressed enzyme that show marked interindividual and interethnic variation. Phenotyping of CYP2D6 provides valuable information about real-time activity of this important drug-metabolizing enzymes through the use of specific probe drugs. The aim of this study was to identify the CYP2D6 oxidation phenotype with dextromethorphan (DEX) as a probe drug in Mazandarani ethnic group among Iranian population.
Methods: The study included 71 unrelated healthy volunteers. Dextromethorphan hydrobromide (30 mg) was given orally to healthy subjects and peripheral venous blood samples (10 ml) were taken at 3 hr post-dose. Dextromethorphan and the metabolite dextrorphan (DOR) were analyzed by the HPLC method. The log DEX/DOR metabolic ratio (MR) at 3 hr plasma sample was used as the index of CYP2D6 activity and a value of 0.3 was used as the antimode separating extensive metabolizers (EM) and poor metabolizers (PM) phenotypes.
Results: A 560-fold interindividual variation in dextromethorphan MRs was observed in this study. Considering the antimode 0.3 in log scale, 7.04% (5/71) volunteers were identified as PMs.
Conclusion: The result showed that the frequency of CYP2D6 PM phenotypes accounted for 7.04% of subjects in our samples. Despite these findings, we propose a further study in larger samples to provide a wider image and to get more valuable information upon pharmacogenetic basis for individual therapy and personalized medicine.
Methods: The study included 71 unrelated healthy volunteers. Dextromethorphan hydrobromide (30 mg) was given orally to healthy subjects and peripheral venous blood samples (10 ml) were taken at 3 hr post-dose. Dextromethorphan and the metabolite dextrorphan (DOR) were analyzed by the HPLC method. The log DEX/DOR metabolic ratio (MR) at 3 hr plasma sample was used as the index of CYP2D6 activity and a value of 0.3 was used as the antimode separating extensive metabolizers (EM) and poor metabolizers (PM) phenotypes.
Results: A 560-fold interindividual variation in dextromethorphan MRs was observed in this study. Considering the antimode 0.3 in log scale, 7.04% (5/71) volunteers were identified as PMs.
Conclusion: The result showed that the frequency of CYP2D6 PM phenotypes accounted for 7.04% of subjects in our samples. Despite these findings, we propose a further study in larger samples to provide a wider image and to get more valuable information upon pharmacogenetic basis for individual therapy and personalized medicine.
Type of Study: Original Article |
Subject:
Infectious Diseases
Received: 2014/01/14 | Accepted: 2014/01/14 | Published: 2014/01/14
Received: 2014/01/14 | Accepted: 2014/01/14 | Published: 2014/01/14
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