Cross-talks between the kidneys and the central nervous system in multiple sclerosis

Rostami, Sahar; Emami Aleagha, Mohammad Sajad; Ghasemi-Kasman, Maryam; Allameh, Abdolamir

doi:10.22088/cjim.9.3.206

Volume 9, Issue 3 (5-2018) Caspian J Intern Med 2018, 9(3): 206-210 | Back to browse issues page

‎ 10.22088/cjim.9.3.206

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Rostami S, Emami Aleagha M S, Ghasemi-Kasman M, Allameh A. Cross-talks between the kidneys and the central nervous system in multiple sclerosis. Caspian J Intern Med 2018; 9 (3) :206-210
URL: http://caspjim.com/article-1-1131-en.html

Cross-talks between the kidneys and the central nervous system in multiple sclerosis

Sahar Rostami

, Mohammad Sajad Emami Aleagha

, Maryam Ghasemi-Kasman

, Abdolamir Allameh

Department of Clinical Biochemistry, Faculty of Medicine, Tarbiat Modarres University, Tehran, Iran , allameha@modares.ac.ir

Abstract: (5740 Views)

Multiple sclerosis (MS) is an inflammatory demyelinating disease, which is considered as a common autoimmune disorder in young adults. A growing number of evidences indicated that the impairment in non-neural tissues plays a significant role in pathology of MS disease. There are bidirectional relationship, metabolic activities and functional similarity between central nervous system (CNS) and kidneys which suggest that kidney tissue may exert remarkable effects on some aspects of MS disorder and CNS impairment in these patients compels the kidney to respond to central inflammation. Recently, it has been well documented that hormonal secretion possesses the important role on CNS abnormalities. In this regard, due to the functional similarity and significant hormonal and non-hormonal relationship between CNS and kidneys, we hypothesized that kidneys exert significant effect on initiation, progression or amelioration of MS disease which might be regarded as potential therapeutic approach in the treatment of MS patients in the future.

Keywords: Multiple sclerosis, Kidneys, Central nervous system, Hormones

Full-Text [PDF 209 kb] (1303 Downloads)

Type of Study: Short Communication | Subject: Neurology
Received: 2017/07/1 | Accepted: 2017/11/26 | Published: 2018/05/7