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:: Volume 9, Issue 3 (5-2018) ::
Caspian J Intern Med 2018, 9(3): 290-295 Back to browse issues page
Glomerular filtration rate determination by creatinine and cystatin-C in patients with acute pyelonephritis
Hadi Sorkhi , Raheleh Behzadi, Neda Joghtaei, Mohammad Poornasrollah, Ali Bijani
Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IR Iran , hadisorkhi@yahoo.com
Abstract:   (2264 Views)

Background: Measurement of glomerular filtration rate (GFR) and monitoring of it in any patient on nephrotoxic drugs is very important. Recently, cystatin C (cys-C) has been introduced as a better marker for determining and monitoring renal function than creatinine especially in a mild decrease of GFR. This study was done to assess the change of GFR measurement based on serum Cys-C and creatinine and their comparison in children with acute pyelonephritis on amikacin.

Methods: All children with acute pyelonephritis who were admitted in Nephrology ward were enrolled in this study. Serum creatinine, serum cys-C and the GFR calculation based on them were measured in patients on the day of admission (day zero) and then on days 3 and 7 after the start of treatment with amikacin and p-value less than 0.05 was considered significant.

Results: Among the 70 children, 61 patients were females and the others were males. Mean age was 42.66±41.53 months. Estimated GFR based on creatinine on day 0 (before amikacin administration), 3 and 7 were 72.41±20.89 ml/min/1.73 m2, 78.42±21.15 ml/min/1.73 m2 and 80.5±22.43 ml/min/1.73 m2, respectively. Moreover, GFR based on cys-C during these days were 116.23±58.9 ml/min/1.73 m2, 116.49±53.31 ml/min/1.73 m2 and 108.37±51.02 ml/min/1.73 m2, respectively (p<0.05).

Conclusions: According to this study, decrease of GFR calculation based on Cys-C was seen and estimated GFR was not changed according to creatinine. So, we recommend the use of cys-C for the monitoring of renal function in any patient treated with nephrotoxic drugs such as amikacin.

Keywords: Nephrotoxicity, Amikacin, Cystatin C, Creatinine, Acute pyelonephritis, Glomerular filtration rate
Full-Text [PDF 495 kb]   (420 Downloads)    
Type of Study: Original Article | Subject: Nephrology
Received: 2017/09/14 | Accepted: 2017/12/4 | Published: 2018/05/12
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Sorkhi H, Behzadi R, Joghtaei N, Poornasrollah M, Bijani A. Glomerular filtration rate determination by creatinine and cystatin-C in patients with acute pyelonephritis. Caspian J Intern Med. 2018; 9 (3) :290-295
URL: http://caspjim.com/article-1-1206-en.html

Volume 9, Issue 3 (5-2018) Back to browse issues page
Caspian Journal of Internal Medicine
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