Caspian Journal of Internal Medicine
Babol University of Medical Sciences
Thu, Mar 20, 2025
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Volume 10, Issue 1 (1-2019)
Caspian J Intern Med 2019, 10(1): 107-110 |
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Montazer F, Sanei-Motlagh A. Neurofolicullar hamartoma presenting as a rare adnexal neoplasm in association with basal cell carcinoma . Caspian J Intern Med 2019; 10 (1) :107-110
URL: http://caspjim.com/article-1-1227-en.html
URL: http://caspjim.com/article-1-1227-en.html
Department of Pathology, Gastrointestinal Cancer Research Center, Imam Hospital, Mazandaran University of Medical Sciences, Sari, Iran , saa_montazer@yahoo.com
Abstract: (5660 Views)
Background: Neurofollicular hamartoma (NFH) is characterized histopathologically by fascicles of spindle cells that laterally delimited by hyperplastic folliculosebaceous units. It usually appears on face, near the nose or nasolabial fold. It does not manifest true neural differentiation and recently the term spindle cell predominant trichodiscoma (SCPT) has been used instead.
Case Presentation: We present a case of a 40-year-old male with co-incidence of NFH and basal cell carcinoma (BCC) that the mesenchymal components of NFH were similar to SCPT but these components highly expressed S-100 protein. We also discuss about the histological aspect of the neoplasia in this report and consider the findings of other reports in association with classification of NFH by means of cellular markers and morphological resemblance to other skin hamartomas.
Conclusion: Neurofollicular hamartoma is a rare benign tumor that thought to represent the cellular end of a morphological spectrum with trichodiscoma. The morphological features and expression of S100 protein in neural element helped us to achieve the diagnosis of neurofollicular hamartoma. However, variable reports of S-100 protein expression in NFH are available and further studies are needed to determine the classification of this tumor.
Case Presentation: We present a case of a 40-year-old male with co-incidence of NFH and basal cell carcinoma (BCC) that the mesenchymal components of NFH were similar to SCPT but these components highly expressed S-100 protein. We also discuss about the histological aspect of the neoplasia in this report and consider the findings of other reports in association with classification of NFH by means of cellular markers and morphological resemblance to other skin hamartomas.
Conclusion: Neurofollicular hamartoma is a rare benign tumor that thought to represent the cellular end of a morphological spectrum with trichodiscoma. The morphological features and expression of S100 protein in neural element helped us to achieve the diagnosis of neurofollicular hamartoma. However, variable reports of S-100 protein expression in NFH are available and further studies are needed to determine the classification of this tumor.
Type of Study: case report |
Subject:
Pathology
Received: 2017/09/30 | Accepted: 2018/07/3 | Published: 2019/01/9
Received: 2017/09/30 | Accepted: 2018/07/3 | Published: 2019/01/9
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