Caspian Journal of Internal Medicine
Babol University of Medical Sciences
Tue, Mar 18, 2025
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Volume 2, Issue 4 (1-2011)
Caspian J Intern Med 2011, 2(4): 326-330 |
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Zahedpasha Y, Ahmadpour-Kacho M, Khalafi J, Bijani A. Cord blood α -fetoprotein as a predictive index for indirect hyperbilirubinemia in term neonates. Caspian J Intern Med 2011; 2 (4) :326-330
URL: http://caspjim.com/article-1-128-en.html
URL: http://caspjim.com/article-1-128-en.html
Abstract: (8080 Views)
Background: Prediction of severe neonatal hyperbilirubinemia is very important for early treatment and prophylaxis of neurologic sequels. The aim of this study was to evaluate the predictive role of umbilical cord α-fetoprotein (UCAFP) as a marker of an increased risk for neonatal hyperbilirubinemia in full term babies.
Methods: Umbilical cord blood was collected from 400 term singleton full term well newborn babies who met our inclusion criteria and stored in -20°C. Those who developed jaundice and admitted for phototherapy (34 newborns: 22 males and 12 females), considered as case group and 31 non-jaundiced infants (13 males and 18 females) gestational age–weight-matched considered as the control group. The serum level of UCAFP was checked in these 65 newborns and was compared between these two groups.
Results: Mean UCAFP in case group was 523.429±174.158 and in control group was 664.548±154.894 µg/L. In the non-jaundiced group, mean UCAFP values was higher than neonate with hyperbilirubinemia (664.548 vs. 523.429µg/L). The mean UCAFP in males was 519.023 µg/L and in females was 531.508 µg/L (p=0.066). Sixty (92.3%) babies delivered by cesarean section (CS) and 5 (7.7%) by normal vaginal delivery (p=0.566).
Conclusion: According to our study, there was no significant positive association between UCAFP and subsequent neonatal indirect hyperbilirubinemia or serum bilirubin level.
Methods: Umbilical cord blood was collected from 400 term singleton full term well newborn babies who met our inclusion criteria and stored in -20°C. Those who developed jaundice and admitted for phototherapy (34 newborns: 22 males and 12 females), considered as case group and 31 non-jaundiced infants (13 males and 18 females) gestational age–weight-matched considered as the control group. The serum level of UCAFP was checked in these 65 newborns and was compared between these two groups.
Results: Mean UCAFP in case group was 523.429±174.158 and in control group was 664.548±154.894 µg/L. In the non-jaundiced group, mean UCAFP values was higher than neonate with hyperbilirubinemia (664.548 vs. 523.429µg/L). The mean UCAFP in males was 519.023 µg/L and in females was 531.508 µg/L (p=0.066). Sixty (92.3%) babies delivered by cesarean section (CS) and 5 (7.7%) by normal vaginal delivery (p=0.566).
Conclusion: According to our study, there was no significant positive association between UCAFP and subsequent neonatal indirect hyperbilirubinemia or serum bilirubin level.
Type of Study: Original Article |
Subject:
Infectious Diseases
Received: 2014/01/15 | Accepted: 2014/01/15 | Published: 2014/01/15
Received: 2014/01/15 | Accepted: 2014/01/15 | Published: 2014/01/15
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