Caspian Journal of Internal Medicine
Babol University of Medical Sciences
Thu, Mar 20, 2025
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Volume 10, Issue 1 (1-2019)
Caspian J Intern Med 2019, 10(1): 11-15 |
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Yazdani M, Ghaemian N, Khafri S, Oliaei F. Can the kidney volume help to differentiate the types of rejection before biopsy?. Caspian J Intern Med 2019; 10 (1) :11-15
URL: http://caspjim.com/article-1-1358-en.html
URL: http://caspjim.com/article-1-1358-en.html
Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran , ol_1964@yahoo.com
Abstract: (6043 Views)
Background: The aim of this study was to use the volume of the graft as an adjunct tool for better decision making.
Methods: Kidney transplanted patients with acute azotemia and documented volume and finally a biopsy were enrolled in this study. Graft volumes between rejected patients (antibody-mediated rejection {AMR} and cell - mediated rejection {CMR}) and non rejected but azotemic patients were compared.
Results: A total of 76 patients were enrolled in this study (45 case and 31 control). 53.3% of the case group were (AMR) and 46.7% belonged to (CMR). There was no difference between kidney volume according to age or sex. But the case group had a significantly bigger volume than controls (253.09 cm3 and 186.45 cm3; p< 0.001). In addition, there was a significant difference between the volumes of AMR kidneys with CMR and controls (286.24+66.70, 224.08+76.79 and 186.95+39.92; P=0.003 and p<0.001, respectively), but not between CMR and controls (P=0.067). A cutoff point of 200 cm3 was determined as rejection with sensitivity and specificity of 70% and a cutoff point of 250 cm3 could be used as AMR cut off with sensitivity of 76% and specificity of 70%.
Conclusion: There was a significant difference in volume between rejection and control group and between AMR and CMR. So, kidney volume determination is an easy and valuable tool to help the clinician to have a more rapid and better decision making.
Methods: Kidney transplanted patients with acute azotemia and documented volume and finally a biopsy were enrolled in this study. Graft volumes between rejected patients (antibody-mediated rejection {AMR} and cell - mediated rejection {CMR}) and non rejected but azotemic patients were compared.
Results: A total of 76 patients were enrolled in this study (45 case and 31 control). 53.3% of the case group were (AMR) and 46.7% belonged to (CMR). There was no difference between kidney volume according to age or sex. But the case group had a significantly bigger volume than controls (253.09 cm3 and 186.45 cm3; p< 0.001). In addition, there was a significant difference between the volumes of AMR kidneys with CMR and controls (286.24+66.70, 224.08+76.79 and 186.95+39.92; P=0.003 and p<0.001, respectively), but not between CMR and controls (P=0.067). A cutoff point of 200 cm3 was determined as rejection with sensitivity and specificity of 70% and a cutoff point of 250 cm3 could be used as AMR cut off with sensitivity of 76% and specificity of 70%.
Conclusion: There was a significant difference in volume between rejection and control group and between AMR and CMR. So, kidney volume determination is an easy and valuable tool to help the clinician to have a more rapid and better decision making.
Type of Study: Original Article |
Subject:
Nephrology
Received: 2018/01/8 | Accepted: 2018/08/6 | Published: 2018/10/28
Received: 2018/01/8 | Accepted: 2018/08/6 | Published: 2018/10/28
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