Caspian Journal of Internal Medicine
Babol University of Medical Sciences
Fri, Nov 22, 2024
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Volume 11, Issue 2 (3-2020)
Caspian J Intern Med 2020, 11(2): 227-230 |
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Salehi M R, Shahi F, Rizvi F S, Ghaderkhani S, Zainaldain H, Khodavaysi S, et al . Combination antifungal therapy without craniotomy in an immunocompromised patient with rhino-orbito-cerebral mucormycosis: A case report. Caspian J Intern Med 2020; 11 (2) :227-230
URL: http://caspjim.com/article-1-1752-en.html
URL: http://caspjim.com/article-1-1752-en.html
Mohammad Reza Salehi 
, Farhad Shahi , Fatema Sadaat Rizvi , Sara Ghaderkhani , Hamed Zainaldain , Sadegh Khodavaysi , Saeed Reza Jamali-Moghaddam , Seyed Ali Dehghan Manshadi * , Omid Rezahosseini
, Farhad Shahi , Fatema Sadaat Rizvi , Sara Ghaderkhani , Hamed Zainaldain , Sadegh Khodavaysi , Saeed Reza Jamali-Moghaddam , Seyed Ali Dehghan Manshadi * , Omid Rezahosseini
Imam Khomeini Complex Hospital, Department of Infectious Diseases, Tehran University of Medical Sciences, Tehran, Iran , sealdema@yahoo.com
Abstract: (4452 Views)
Background: Mucormycosis is an uncommon fungal infection caused by the members of the order Mucorales. In susceptible patients, mucormycosis can infect any tissue or organ, and without suitable treatment (i.e., debridement and antifungal therapy), this infection can be fatal. Our patient was a woman with lymphoma and cerebral mucormycosis who was treated with antifungals and without any neurosurgical debridement.
Case Presentation: Herein, we present the case of a 35-year-old woman with diagnosis of B-cell lymphoma and rhino-orbito-cerebral mucormycosis (ROCM). She was a candidate for enucleation of the left eye, orbital decompression, and sinocerebral debridement. Nevertheless, the patient refused eye enucleation and craniotomy. Finally, she was treated with a combination of antifungals and sinus debridement without eye enucleation and craniotomy.
Conclusion: Endoscopic debridement, along with a combination of liposomal amphotericin B (LAMB) and posaconazole, may be a suitable therapeutic option for patients with ROCM, who are not eligible candidates for extensive surgery or craniotomy.
Case Presentation: Herein, we present the case of a 35-year-old woman with diagnosis of B-cell lymphoma and rhino-orbito-cerebral mucormycosis (ROCM). She was a candidate for enucleation of the left eye, orbital decompression, and sinocerebral debridement. Nevertheless, the patient refused eye enucleation and craniotomy. Finally, she was treated with a combination of antifungals and sinus debridement without eye enucleation and craniotomy.
Conclusion: Endoscopic debridement, along with a combination of liposomal amphotericin B (LAMB) and posaconazole, may be a suitable therapeutic option for patients with ROCM, who are not eligible candidates for extensive surgery or craniotomy.
Keywords: Mucormycosis, Invasive fungal infection, Combination drug therapies, Liposomal amphotericin B, Posaconazole
Type of Study: case report |
Subject:
Infectious Diseases
Received: 2019/02/4 | Accepted: 2019/06/26 | Published: 2020/04/22
Received: 2019/02/4 | Accepted: 2019/06/26 | Published: 2020/04/22
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