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:: Volume 4, Issue 2 (1-2013) ::
Caspian J Intern Med 2013, 4(2): 654-657 Back to browse issues page
Increased cefepime MIC for enterobacteriacae clinical isolates
Narges Najafi *, Ahmad Alikhani, Farhang Babamahmoudi, AliReza Davoudi, Roya Ghasemiyan, Shahriar Aliyan, Arman Shoujaiifar
Abstract:   (4887 Views)
Background: Cefepime was used as empirical treatment in ventilator-associated pneumonia (VAP) induced by gram-negative and gram-positive bacteria. This study aimed to determine the antimicrobial susceptibility pattern of cefepime against microorganism causing VAP in Mazandaran, North of Iran.
Methods: This study was performed on VAP patients diagnosed with clinical pulmonary infection score (CPIS) scores in ICU of two hospitals. For each patient suspected of having VAP, quantitative culture of endotracheal aspiration (QEA) was performed and MIC was determined by micro dilution test. Data were collected and analyzed.
Results: Thirty- five cases of enterobacteriaceae were isolated orderly including E coli 13, P. aeruginosa 11, Enterobacter 7 and K. pneumonia 4 cases. All the isolated E. coli, Enterobacter and Klebsiella, 54.5% of P. aeruginosa isolated were fully resistant to cefepime.
Conclusion: The results of this study show that cefepime is not a reasonable choice for empirical treatment of nosocomial pneumonia and VAP.
Keywords: Cefepime, Enterobacteriacae, MIC, VAP, ICU.
Full-Text [PDF 103 kb]   (1238 Downloads)    
Type of Study: Original Article | Subject: Infectious Diseases
Received: 2014/01/15 | Accepted: 2014/01/15 | Published: 2014/01/15
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Najafi N, Alikhani A, Babamahmoudi F, Davoudi A, Ghasemiyan R, Aliyan S et al . Increased cefepime MIC for enterobacteriacae clinical isolates. Caspian J Intern Med. 2013; 4 (2) :654-657
URL: http://caspjim.com/article-1-197-en.html

Volume 4, Issue 2 (1-2013) Back to browse issues page
Caspian Journal of Internal Medicine
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