Caspian Journal of Internal Medicine
Babol University of Medical Sciences
Fri, Oct 11, 2024
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Volume 12 - Case Supplement
Caspian J Intern Med 2021, 12 - Case Supplement : 383-387 |
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Mosannen Mozafari P, Salek R, Taghizadeh A, Yazdanpanah M J, Mosannen Mozaffari H, Esmaeili E. diagnosis of an occult gastric adenocarcinoma by oral manifestations (acanthosis nigricans) : a case report. Caspian J Intern Med 2021; 12 (S2) :383-387
URL: http://caspjim.com/article-1-2126-en.html
URL: http://caspjim.com/article-1-2126-en.html
Pegah Mosannen Mozafari 
, Roham Salek , Ava Taghizadeh , Mohammad Javad Yazdanpanah , Homan Mosannen Mozaffari , Elham Esmaeili *
, Roham Salek , Ava Taghizadeh , Mohammad Javad Yazdanpanah , Homan Mosannen Mozaffari , Elham Esmaeili *
Department of Oral Medicine, School of Dentistry, Birjand University of Medical Sciences, Birjand, Iran , esmaeilie961@mums.ac.ir
Abstract: (2607 Views)
Background: Acanthosis nigricans (AN) is a condition with an important characteristics of symmetrical areas of thickened skin with grayish brown Hyperpigmentation. The mucosa may show a papillomatous surface, with or without hyperpigmentation. Lips and sites at risk of trauma may be affected and palmoplantar might also be present. In some rare cases, acanthosis nigricans presents as a sign of internal neoplasia, mostly a gastrointestinal cancer, and is called malignant acanthosis nigricans (MAN).
Case Presentation: In this study, a 55-year-old female Iranian patient with malignant acanthosis nigricans (MAN) is reported. She was seeking esthetic treatment for her oral and perioral regions. The peculiarity of this case is simultaneous skin manifestation consistent with MAN, “tripe palms,”(TP) , and Leser-Trélat (LT) sign and mucosal changes in the oral cavity such as papillomatosis and roughened surfaces of the lips, hard palate and buccal mucosa. These changes harbored gastric adenocarcinoma stage T3 N3, but the patient was asymptomatic except for pruritis.
Conclusion: There is an urgent need to suspect a correlation between oral and skin changes and the possibility of an internal neoplasia, therefore it is of utmost importance to refer these patients for early diagnosis of the underlying disease. This would improve the prognosis and lessen the consequences to a great extent.
Case Presentation: In this study, a 55-year-old female Iranian patient with malignant acanthosis nigricans (MAN) is reported. She was seeking esthetic treatment for her oral and perioral regions. The peculiarity of this case is simultaneous skin manifestation consistent with MAN, “tripe palms,”(TP) , and Leser-Trélat (LT) sign and mucosal changes in the oral cavity such as papillomatosis and roughened surfaces of the lips, hard palate and buccal mucosa. These changes harbored gastric adenocarcinoma stage T3 N3, but the patient was asymptomatic except for pruritis.
Conclusion: There is an urgent need to suspect a correlation between oral and skin changes and the possibility of an internal neoplasia, therefore it is of utmost importance to refer these patients for early diagnosis of the underlying disease. This would improve the prognosis and lessen the consequences to a great extent.
Type of Study: case report |
Subject:
Oncology
Received: 2019/11/26 | Accepted: 2020/01/15 | Published: 2021/07/24
Received: 2019/11/26 | Accepted: 2020/01/15 | Published: 2021/07/24
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