Caspian Journal of Internal Medicine
Babol University of Medical Sciences
پنجشنبه 30 اسفند 1403
[Archive]
دوره 11، شماره 4 - ( 4-1399 )
جلد 11 شماره 4 صفحات 425-419 |
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Motallebnejad M, Zahedpasha S, Moghadamnia A A, Kazemi S, Moslemi D, Pouramir M et al . Protective effect of lycopene on oral mucositis and antioxidant capacity of blood plasma in the rat exposed to gamma radiation. Caspian J Intern Med 2020; 11 (4) :419-425
URL: http://caspjim.com/article-1-2157-fa.html
URL: http://caspjim.com/article-1-2157-fa.html
Protective effect of lycopene on oral mucositis and antioxidant capacity of blood plasma in the rat exposed to gamma radiation. . 1399; 11 (4) :419-425
چکیده: (3970 مشاهده)
Background: Nowadays, radiotherapy is used effectively for treatment of head and neck cancers. Mucositis is one of the most important side effects of radiotherapy. Radio-protective agents protect tissues and cells against the adverse effects due to ionizing radiation and cleave radiation-induced free radicals. Lycopene as a potent antioxidant protects cells against oxidative damage by free radical–scavenging. The present study investigated the antioxidant effect of lycopene on oral mucosa of irradiated rats.
Methods: In this experimental animal study, 28 rats were placed in four groups as follows: treated with 50 mg /kg of lycopene (L50), solvent+irradiation (SR), 25 mg / kg of lycopene+irradiation (LR25), and 50 mg / kg of lycopene+irradiation (LR50). The rats received lycopene intraperitoneally. On the irradiation day (day 0) and tenth day of radiation, blood samples were taken from the animals for FRAP and TBARS tests.
Results: The results showed that the LR50 group didn’t show mucositis higher than Grade 2. There was a significant difference (p <0.05) between SR and the L50 regarding the severity of mucositis. In addition, L50 showed higher antioxidant activity and lower peroxidation than SR.
Conclusion: The lycopene reduced the severity of mucositis. Therefore, it can be used as a potential and promising nutritional substance to prevent radiotherapy complications, especially in the treatment of head and neck cancers. However, further research is necessary to confirm these results.
Methods: In this experimental animal study, 28 rats were placed in four groups as follows: treated with 50 mg /kg of lycopene (L50), solvent+irradiation (SR), 25 mg / kg of lycopene+irradiation (LR25), and 50 mg / kg of lycopene+irradiation (LR50). The rats received lycopene intraperitoneally. On the irradiation day (day 0) and tenth day of radiation, blood samples were taken from the animals for FRAP and TBARS tests.
Results: The results showed that the LR50 group didn’t show mucositis higher than Grade 2. There was a significant difference (p <0.05) between SR and the L50 regarding the severity of mucositis. In addition, L50 showed higher antioxidant activity and lower peroxidation than SR.
Conclusion: The lycopene reduced the severity of mucositis. Therefore, it can be used as a potential and promising nutritional substance to prevent radiotherapy complications, especially in the treatment of head and neck cancers. However, further research is necessary to confirm these results.
نوع مطالعه: Original Article |
موضوع مقاله:
Dentistry
دریافت: 1398/10/4 | پذیرش: 1398/11/23 | انتشار: 1396/4/24
دریافت: 1398/10/4 | پذیرش: 1398/11/23 | انتشار: 1396/4/24
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