Caspian Journal of Internal Medicine
Babol University of Medical Sciences
Thu, Dec 26, 2024
[Archive]
Volume 11, Issue 4 (6-2020)
Caspian J Intern Med 2020, 11(4): 419-425 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Motallebnejad M, Zahedpasha S, Moghadamnia A A, Kazemi S, Moslemi D, Pouramir M et al . Protective effect of lycopene on oral mucositis and antioxidant capacity of blood plasma in the rat exposed to gamma radiation. Caspian J Intern Med 2020; 11 (4) :419-425
URL: http://caspjim.com/article-1-2157-en.html
URL: http://caspjim.com/article-1-2157-en.html
Mina Motallebnejad 
, Shaghayegh Zahedpasha , Ali Akbar Moghadamnia , Sohrab Kazemi , Daryoush Moslemi , Mahdi Pouramir , Fariba Asgharpour *
, Shaghayegh Zahedpasha , Ali Akbar Moghadamnia , Sohrab Kazemi , Daryoush Moslemi , Mahdi Pouramir , Fariba Asgharpour *
Dental Materials Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran , f_asgharpour@yahoo.com
Abstract: (3825 Views)
Background: Nowadays, radiotherapy is used effectively for treatment of head and neck cancers. Mucositis is one of the most important side effects of radiotherapy. Radio-protective agents protect tissues and cells against the adverse effects due to ionizing radiation and cleave radiation-induced free radicals. Lycopene as a potent antioxidant protects cells against oxidative damage by free radical–scavenging. The present study investigated the antioxidant effect of lycopene on oral mucosa of irradiated rats.
Methods: In this experimental animal study, 28 rats were placed in four groups as follows: treated with 50 mg /kg of lycopene (L50), solvent+irradiation (SR), 25 mg / kg of lycopene+irradiation (LR25), and 50 mg / kg of lycopene+irradiation (LR50). The rats received lycopene intraperitoneally. On the irradiation day (day 0) and tenth day of radiation, blood samples were taken from the animals for FRAP and TBARS tests.
Results: The results showed that the LR50 group didn’t show mucositis higher than Grade 2. There was a significant difference (p <0.05) between SR and the L50 regarding the severity of mucositis. In addition, L50 showed higher antioxidant activity and lower peroxidation than SR.
Conclusion: The lycopene reduced the severity of mucositis. Therefore, it can be used as a potential and promising nutritional substance to prevent radiotherapy complications, especially in the treatment of head and neck cancers. However, further research is necessary to confirm these results.
Methods: In this experimental animal study, 28 rats were placed in four groups as follows: treated with 50 mg /kg of lycopene (L50), solvent+irradiation (SR), 25 mg / kg of lycopene+irradiation (LR25), and 50 mg / kg of lycopene+irradiation (LR50). The rats received lycopene intraperitoneally. On the irradiation day (day 0) and tenth day of radiation, blood samples were taken from the animals for FRAP and TBARS tests.
Results: The results showed that the LR50 group didn’t show mucositis higher than Grade 2. There was a significant difference (p <0.05) between SR and the L50 regarding the severity of mucositis. In addition, L50 showed higher antioxidant activity and lower peroxidation than SR.
Conclusion: The lycopene reduced the severity of mucositis. Therefore, it can be used as a potential and promising nutritional substance to prevent radiotherapy complications, especially in the treatment of head and neck cancers. However, further research is necessary to confirm these results.
Type of Study: Original Article |
Subject:
Dentistry
Received: 2019/12/25 | Accepted: 2020/02/12 | Published: 2017/07/15
Received: 2019/12/25 | Accepted: 2020/02/12 | Published: 2017/07/15
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
