Caspian Journal of Internal Medicine
Babol University of Medical Sciences
جمعه 3 اسفند 1403
[Archive]
دوره 12، شماره 2 - ( 12-1399 )
جلد 12 شماره 2 صفحات 199-194 |
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Gholizadeh A, Mehrabani S, Esmaeili Dooki M, Haji Ahmadi M. Effect of a synbiotic on functional abdominal pain in childhood. Caspian J Intern Med 2021; 12 (2) :194-199
URL: http://caspjim.com/article-1-2247-fa.html
URL: http://caspjim.com/article-1-2247-fa.html
Effect of a synbiotic on functional abdominal pain in childhood. . 1399; 12 (2) :194-199
چکیده: (3759 مشاهده)
Background: One of the common functional gastrointestinal disorders in children is functional abdominal pain (FAP). The aim of the present study was to determine whether the administration of a synbiotic composed of fructo-oligosaccharides (FOS) and the seven types of beneficial bacteria is useful in FAP of childhood.
Methods: In this placebo-controlled, double-blind trial, 4-15-year-old children who met the Rome III criteria for FAP were randomly divided to receive either synbiotic or placebo twice daily for 4 weeks. Primary outcome was at least 50% reduction in the number of pain episodes, and secondary outcomes were a decline of at least two scales in the pain duration and intensity based on Wong-Baker scale. Response to therapy was decrease of pain frequency/intensity.
Results: A total of 67 children completed the trial (35 with synbiotic). Response rate was higher with synbiotic than placebo after four weeks (53.1 vs 11.4%; p<0.001), and synbiotic had significant superiority to placebo to relieve the duration (4.56±9.12 vs12±18.59, min/day, P=0.04), frequency (0.31±0.53vs 1.17±0.7, episode/Wk., P<.001) and intensity (2.38±2.29 vs 5.49±1.83, p<0.001) of abdominal pain.
Conclusion: Synbiotic compared to placebo significantly decreased the intensity, frequency and duration of FAP in children.
Methods: In this placebo-controlled, double-blind trial, 4-15-year-old children who met the Rome III criteria for FAP were randomly divided to receive either synbiotic or placebo twice daily for 4 weeks. Primary outcome was at least 50% reduction in the number of pain episodes, and secondary outcomes were a decline of at least two scales in the pain duration and intensity based on Wong-Baker scale. Response to therapy was decrease of pain frequency/intensity.
Results: A total of 67 children completed the trial (35 with synbiotic). Response rate was higher with synbiotic than placebo after four weeks (53.1 vs 11.4%; p<0.001), and synbiotic had significant superiority to placebo to relieve the duration (4.56±9.12 vs12±18.59, min/day, P=0.04), frequency (0.31±0.53vs 1.17±0.7, episode/Wk., P<.001) and intensity (2.38±2.29 vs 5.49±1.83, p<0.001) of abdominal pain.
Conclusion: Synbiotic compared to placebo significantly decreased the intensity, frequency and duration of FAP in children.
نوع مطالعه: Original Article |
موضوع مقاله:
Gastroentrology
دریافت: 1398/12/28 | پذیرش: 1399/5/11 | انتشار: 1400/1/10
دریافت: 1398/12/28 | پذیرش: 1399/5/11 | انتشار: 1400/1/10
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