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:: Volume 12, Issue 2 (3-2021) ::
Caspian J Intern Med 2021, 12(2): 194-199 Back to browse issues page
Effect of a synbiotic on functional abdominal pain in childhood
Azade Gholizadeh , Sanaz Mehrabani , Mohammadreza Esmaeili Dooki , Mahmood Haji Ahmadi
Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran , mehrabanisanaz@gmail.com
Abstract:   (139 Views)
Background: One of the common functional gastrointestinal disorders in children is functional abdominal pain (FAP). The aim of the present study was to determine whether the administration of a synbiotic composed of fructo-oligosaccharides (FOS) and the seven types of beneficial bacteria is useful in FAP of childhood.
Methods: In this placebo-controlled, double-blind trial, 4-15-year-old children who met the Rome III criteria for FAP were randomly divided to receive either synbiotic or placebo twice daily for 4 weeks. Primary outcome was at least 50% reduction in the number of pain episodes, and secondary outcomes were a decline of at least two scales in the pain duration and intensity based on Wong-Baker scale. Response to therapy was decrease of pain frequency/intensity.
Results: A total of 67 children completed the trial (35 with synbiotic). Response rate was higher with synbiotic than placebo after four weeks (53.1 vs 11.4%; p<0.001), and synbiotic had significant superiority to placebo to relieve the duration (4.56±9.12 vs12±18.59, min/day, P=0.04), frequency (0.31±0.53vs 1.17±0.7, episode/Wk., P<.001) and intensity (2.38±2.29 vs 5.49±1.83, p<0.001) of abdominal pain.
Conclusion: Synbiotic compared to placebo significantly decreased the intensity, frequency and duration of FAP in children.
Keywords: Abdominal pain, Child, Synbiotic.
Full-Text [PDF 226 kb]   (42 Downloads)    
Type of Study: Original Article | Subject: Gastroentrology
Received: 2020/03/18 | Accepted: 2020/08/1 | Published: 2021/03/30
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Gholizadeh A, Mehrabani S, Esmaeili Dooki M, Haji Ahmadi M. Effect of a synbiotic on functional abdominal pain in childhood. Caspian J Intern Med. 2021; 12 (2) :194-199
URL: http://caspjim.com/article-1-2247-en.html


Volume 12, Issue 2 (3-2021) Back to browse issues page
Caspian Journal of Internal Medicine
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