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:: Volume 12, Issue 2 (Spring 2021) ::
Caspian J Intern Med 2021, 12(2): 173-179 Back to browse issues page
Prevalence and Viral Load Determination of BK Polyomavirus among Iranian Patients with Brain Tumors
Saghar Saber Amoli , Arqavan Zebardast , Hossein Keyvani , Yousef Yahyapour , Seyed Mohammad Ghodsi , Mahmood Maniati , Farzin Sadeghi
Cellular & Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran , sadeghifarzin6@gmail.com
Abstract:   (3812 Views)
Background: Due to persistent infections of human central nervous system (CNS), polyomaviruses have been identified as one of the risk factors for brain tumor development. Human BK virus is of significant interest due to its experimental neuro-oncogenic potential and the possible association with CNS neoplasms. However, the results of different studies are discrepant. In the present study, we aimed to investigate the prevalence of BK virus genome and quantify BK viral load in Iranian patients with primary and metastatic brain malignancies.
Methods: To assess the prevalence of BK virus sequences, a total of 58 fresh brain tumors were examined by quantitative real-time PCR. The BK viral load was determined as viral copy number per cell.
Results: Of the 58 brain tumor samples BK tumor antigen (TAg) sequences were detected in 26 (44.8%) of cases. In primary brain tumors, BK virus sequences were recognized more frequently in schwannomas (15.5%) and meningiomas (12.1%). The mean BK virus TAg copy number in positive cases was 0.20×10-3±0.27×10-3 (range 0.01×10-3- 0.8×10-3) copies per cell.
Conclusion: Taken together, in the present study low copy numbers of BK virus TAg gene was detected in brain tumor cells, which can indicate that BK virus may contribute to tumor induction by indirect mechanisms or neuro-persistence of this virus without any pathological consequences.
Keywords: BK Human Polyomavirus, Brain tumors, Tumor Antigen
Full-Text [PDF 213 kb]   (695 Downloads)    
Type of Study: Original Article | Subject: Microbiology
Received: 2020/07/3 | Accepted: 2020/08/12 | Published: 2021/03/30
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Saber Amoli S, Zebardast A, Keyvani H, Yahyapour Y, Ghodsi S M, Maniati M et al . Prevalence and Viral Load Determination of BK Polyomavirus among Iranian Patients with Brain Tumors. Caspian J Intern Med 2021; 12 (2) :173-179
URL: http://caspjim.com/article-1-2407-en.html

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Volume 12, Issue 2 (Spring 2021) Back to browse issues page
Caspian Journal of Internal Medicine
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