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:: Volume 13, Issue 4 (Autumn 2022) ::
Caspian J Intern Med 2022, 13(4): 650-665 Back to browse issues page
Soluble urokinase plasminogen activator receptor (suPAR) in the emergency department: An update
Dimitrios Velissaris , Nicholas Zareifopoulos * , Vasileios Karamouzos , Charalampos Pierrakos , Menelaos Karanikolas
Department of Internal Medicine, University Hospital of Patras, Patras, Greece , nizareifopoulos@gmail.com
Abstract:   (1210 Views)

Background: The biomarker soluble urokinase plasminogen activator receptor (suPAR) is an indicator of inflammation which is increased in a variety of chronic and acute disease states. Its most promising application in the emergency setting is to aid in the prognostic stratification of patients by identifying those at high risk of deterioration. This is a narrative review of studies evaluating the use of suPAR
Methods: We conducted a Medline search for studies on the use of suPAR in patients acutely admitted to the emergency department.
Results: 25 original studies were included in the review. suPAR as a marker of inflammation has been used alone or combined to other inflammatory biomarkers in the assessment of patients suffering from various acute and chronic diseases in an emergency setting. As it is non-specific, it may increase in infectious disease, malignancy or acute coronary syndromes among other conditions, but quantitative suPAR levels correlate with disease severity. It may be useful for the identification of high risk patients regardless of underlying pathology.
Conclusion: As the ideal biomarker in the emergency setting has not been identified yet, suPAR may be a promising addition to the established biomarkers for the initial assessment of patients in this setting. Additional research is necessary to evaluate the usefulness of suPAR guided management algorithms.

Keywords: suPAR, Biomarker, Emergency Department, Mortaliti, Infection, Sepsis
Full-Text [PDF 237 kb]   (457 Downloads)    
Type of Study: Review Article | Subject: Internal
Received: 2021/01/18 | Accepted: 2021/12/5 | Published: 2022/09/19
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Velissaris D, Zareifopoulos N, Karamouzos V, Pierrakos C, Karanikolas M. Soluble urokinase plasminogen activator receptor (suPAR) in the emergency department: An update. Caspian J Intern Med 2022; 13 (4) :650-665
URL: http://caspjim.com/article-1-2714-en.html

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Volume 13, Issue 4 (Autumn 2022) Back to browse issues page
Caspian Journal of Internal Medicine
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