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:: دوره 13، شماره 3 - ( 3-1401 ) ::
جلد 13 شماره 3 صفحات 474-469 برگشت به فهرست نسخه ها
Post-neurosurgical meningitis; gram negative bacilli vs. gram positive cocci
چکیده:   (365 مشاهده)
Background: Post-neurosurgical meningitis is a significant cause of mortality and morbidity. In this study we aimed to compare the differences of clinical, laboratory features and outcomes between the post-neurosurgical meningitis caused by gram-negative bacilli (GNB) and gram-positive cocci (GPC).
Methods: Cases of post-neurosurgical meningitis (with positive CSF culture) were included. After classifying patients as GNB and GPC groups, clinical and paraclinical data were compared.
Results: Out of 2667 neurosurgical patients, CSF culture was positive in 45 patients. 25 (54.3%) were GNB, 19 (41.3%) GPC. The most common microorganisms were Klebsiella pneumoniae (n=14, 31.1%), Coagulase negative staphylococcus (n=8, 17.8%), Staphylococcus aureus (n=6, 13.3%), Acinetobacter baumannii (n=4, 8.9%), Pseudomonas aeruginosa (n=2, 4.4%), and Escherichia coli (n=2, 4.4%). There were no correlation between CSF Leakage, Surgical site appearance, presence of drain, Age and GCS between two groups (P=0.11, P=0.28, P=0.06, P=0.86, P=0.11 respectively). The only different laboratory indexes were ESR (86.8 mm/h vs. 59.5 mm/h, P=0.01) and PCT (13.1 ng/ml vs. 0.8 ng/ml, P=0.02) which were higher in GNB cases. 20% (n=5) of patients with GNB meningitis received preoperative corticosteroid, while none of GPC cases received (P=0.03). The median length of hospitalization for GNB and GPC cases was 56 and 44.4 days respectively (P=0.3).
Conclusion: The GNB antibiotic coverage should be designed more carefully in post-neurosurgical meningitis especially in patients with recent corticosteroid therapy and elevated ESR and procalcitonin.
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نوع مطالعه: Original Article | موضوع مقاله: Infectious Diseases
دریافت: 1400/1/4 | پذیرش: 1400/4/14 | انتشار: 1401/3/11
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Zeinalizadeh M, Yazdani R, Feizabadi M M, Shadkam M, Seifi A, Dehghan Manshadi S A, et al . Post-neurosurgical meningitis; gram negative bacilli vs. gram positive cocci. Caspian J Intern Med. 2022; 13 (3) :469-474
URL: http://caspjim.com/article-1-2817-fa.html

Post-neurosurgical meningitis; gram negative bacilli vs. gram positive cocci. 1. 1401; 13 (3) :474-469

URL: http://caspjim.com/article-1-2817-fa.html



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دوره 13، شماره 3 - ( 3-1401 ) برگشت به فهرست نسخه ها
Caspian Journal of Internal Medicine
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