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Effectiveness of probiotics on chronic urticaria: A randomized clinical trial study
Abbas Dabbaghzadeh , Javad Ghaffari * , Siavash Moradi , Davood Sayadian separghan
Mazandaran University of Medical Sciences, Sari, Iran , javadneg@yahoo.com
Abstract:   (781 Views)
Background: Urticaria is a common itchy skin condition characterized by swelling and erythema. Different treatments are available today.The purpose of this study was to evaluate the clinical effects of probiotic use in patients with chronic resistant urticaria.
Methods: This four-way blind randomized clinical trial was conducted during June-November 2019. Population consisted of patients with chronic urticaria who didn’t response well to first line treatment with antihistamine. For the intervention group, antihistamine (cetirizine) and probiotics (Femilact capsule) and for the control group, antihistamine (Cetirizine) and placebo was administered twice a day for 8 weeks. The urticarial activity for 7 days (UAS7) questionnaire was used to assess the urticaria activity and the Dermatology Life Quality Index (DLQI) questionnaire was used to assess the quality of life of patients. Results: Patients’ age range was 7-30 years with a mean and standard deviation of 23.6 ± 9.2 years. 31 cases (81.57%) were female and 7 cases (18.42%) were male. Twenty patients were in the intervention group and eighteen patients were in the control group. The mean scores of UAS7 questionnaire was reduced in both groups, but it was more significant in the intervention group (9.6±6.4) compared to control group (12.7±8.1) at 8 weeks after treatment (P=0.036). Also, there was no significant difference in quality of life mean score between the two groups after 8 weeks (P=0.805).
Conclusion: this study showed that probiotic consumption along with antihistamines significantly improved the activity of urticarial but not the quality of life of patients.
Keywords: chronic urticaria, histamine antagonists, probiotics, therapeutics
Type of Study: Original Article | Subject: Dermathology
Received: 2021/05/2 | Accepted: 2022/01/26
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Caspian Journal of Internal Medicine
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