Caspian Journal of Internal Medicine
Babol University of Medical Sciences
Thu, Dec 26, 2024
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Volume 13, Issue 4 (Autumn 2022)
Caspian J Intern Med 2022, 13(4): 728-734 |
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Ghalehnoei H, Hormati A, Mohammad Alizadeh A H, Ahmadpour S, Abedi S H. Patient-related post-ERCP pancreatitis (PEP) risk factors between two groups of patients: Prophylactic pancreatic stent and rectal indomethacin. Caspian J Intern Med 2022; 13 (4) :728-734
URL: http://caspjim.com/article-1-3033-en.html
URL: http://caspjim.com/article-1-3033-en.html
Hossein Ghalehnoei 
, Ahmad Hormati , Amir Houshang Mohammad Alizadeh , Sajjad Ahmadpour , Seyed Hassan Abedi *
, Ahmad Hormati , Amir Houshang Mohammad Alizadeh , Sajjad Ahmadpour , Seyed Hassan Abedi *
Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol Iran , h.abedi@mubabol.ac.ir
Abstract: (1868 Views)
Background: Pancreatitis is one of the most crucial complications following endoscopic retrograde cholangiopancreatography (ERCP). The purpose of the current study was to investigate patient-related post-ERCP pancreatitis (PEP) risk factors in two groups of patients: prophylactic pancreatic stent and rectal indomethacin.
Methods: Two different prophylactic modalities were planned and complications were assessed based on the defined inclusion criteria. In this study, the patients were evaluated for the procedure and patient-related risk factors in post-ERCP pancreatitis in the recipient groups of the prophylactic pancreatic stent and rectal indomethacin.
Results: Pancreatitis was confirmed in 27 of all 170 selected patients after ERCP. By univariate analysis, two variables were significant with the development of PEP. Regarding the patient-related risk factors, unique subjects with common bile duct (CBD) dilated 10mm were more exposed to an increased chance of PEP (P=0. 015); meanwhile, other factors did not correlate with the increased possibility of PEP in both groups. The only procedure-related risk factor for PEP was the deep cannulation of the pancreatic duct in both groups during the procedure with an incremental significant incidence of pancreatitis (P=0.005). Comparison of prophylactic pancreatic stent and rectal indomethacin showed no effects in term of post ERCP pancreatitis reduction. Additionally, there was no significant difference between these two strategies in the rate of PEP.
Conclusion: Prophylactic pancreatic duct stents and administration of rectal indomethacin cannot have particular approaches for reducing the possible occurrence of PEP. The increase in time of deep cannulation and the presence of CBD dilation <10mm could be considered as important risk factors.
Methods: Two different prophylactic modalities were planned and complications were assessed based on the defined inclusion criteria. In this study, the patients were evaluated for the procedure and patient-related risk factors in post-ERCP pancreatitis in the recipient groups of the prophylactic pancreatic stent and rectal indomethacin.
Results: Pancreatitis was confirmed in 27 of all 170 selected patients after ERCP. By univariate analysis, two variables were significant with the development of PEP. Regarding the patient-related risk factors, unique subjects with common bile duct (CBD) dilated 10mm were more exposed to an increased chance of PEP (P=0. 015); meanwhile, other factors did not correlate with the increased possibility of PEP in both groups. The only procedure-related risk factor for PEP was the deep cannulation of the pancreatic duct in both groups during the procedure with an incremental significant incidence of pancreatitis (P=0.005). Comparison of prophylactic pancreatic stent and rectal indomethacin showed no effects in term of post ERCP pancreatitis reduction. Additionally, there was no significant difference between these two strategies in the rate of PEP.
Conclusion: Prophylactic pancreatic duct stents and administration of rectal indomethacin cannot have particular approaches for reducing the possible occurrence of PEP. The increase in time of deep cannulation and the presence of CBD dilation <10mm could be considered as important risk factors.
Type of Study: Original Article |
Subject:
Gastroentrology
Received: 2021/08/1 | Accepted: 2022/01/26 | Published: 2022/09/28
Received: 2021/08/1 | Accepted: 2022/01/26 | Published: 2022/09/28
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