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:: Volume 13, Issue 2 (Spring 2022) ::
Caspian J Intern Med 2022, 13(2): 385-392 Back to browse issues page
Clinical Laboratory Parameters in Different Stages, Zones, and Remission/Progression statuses of Retinopathy of Prematurity
Seyed Ahmad Rasoulinejad * , Faezeh Maroufi , Ahad Alizadeh
Department of Ophthalmology, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran , Seyedahmadrasoulinejad@gmail.com
Abstract:   (1281 Views)
Background: Retinopathy of prematurity (ROP) is a vasoproliferative retinal disease in premature infants that causes lifetime visual impairment and blindness in the early ages. In this study, we investigated the differences in the values of clinical laboratory parameters between different ROP and its remission/progression statuses regarding stages and zones.
Methods: This historical cohort study includes 828 infants divided into two groups after the first examination containing ROP infants and controls. The biochemical and hematological parameters of the two groups have been collected from the patient’s history.
Results: In infants with ROP, the hematopoiesis-related parameters, including the mean level of hemoglobin, total bilirubin, potassium, calcium were significantly less than controls (P =0.039, P =0.001, P =0.001, and P=0.046, respectively). The percentages of reticulocyte and the levels of BUN in ROP patients were significantly higher than in normal infants (P=0.015 and p <0.001, respectively). Moreover, the levels of hemoglobin and BUN were significantly different in the different zones of ROP (P=0.017 and P=0.001, respectively). Also, higher hemoglobin levels, total bilirubin, and CRP were observed in the reduced stages of ROP (P=0.041, P=0.045, and P=0.039, respectively).
Conclusion: Laboratory parameters are different in different stages, zones and remission/progression ROP infants.
Keywords: Retinopathy of prematurity, Prognosis, Laboratory parameters, Hematologic parameters, Biochemical parameters.
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Type of Study: Original Article | Subject: Ophtalmology
Received: 2021/09/5 | Accepted: 2021/11/22 | Published: 2022/02/2
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Rasoulinejad S A, Maroufi F, Alizadeh A. Clinical Laboratory Parameters in Different Stages, Zones, and Remission/Progression statuses of Retinopathy of Prematurity. Caspian J Intern Med. 2022; 13 (2) :385-392
URL: http://caspjim.com/article-1-3085-en.html

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Volume 13, Issue 2 (Spring 2022) Back to browse issues page
Caspian Journal of Internal Medicine
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