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:: Volume 14, Issue 2 (Spring 2023) ::
Caspian J Intern Med 2023, 14(2): 401-405 Back to browse issues page
Langerhans cell histiocytosis presented as bilateral otitis media with effusion, a rare case report
Soheil Motamed , Maryam Amizadeh * , Shahriar Dabiri
Department of Otorhinolaryngology, Afzalipour faculty of medicine, Kerman University of Medical Sciences, Kerman, Iran , amizade.m@yahoo.com
Abstract:   (266 Views)
Background: Langerhans cell histiocytosis (LCH) or histiocytosis X is considered as a rare disease that may have effect on multiple organs. The initial presentation of LCH is varied. The signs and symptoms of otologic histiocytosis can be the same as the acute or chronic infectious ear diseases. Definitive diagnosis of LCH is confirmed by biopsy and immunohistochemically staining of S-100 protein and CD1a antigen. Chemotherapy is the main mode of treatment.
Case presentation: In this report, we explained the clinical manifestation, diagnosis and treatment of a case of 15 month-old girl with diagnosed of LCH that initially presented with otitis media with effusion (OME).
Conclusion: LCH is a rare disease that presented with variable sign and symptoms and have an effect on multiple organs. LCH should be regarded in cases with recurrent ear infection without response to medical treatments. Moreover, biopsy with IHC is the gold standard of diagnosis and chemotherapy is the main form of treatment.

Keywords: Langerhans cell histiocytosis, histiocytosis X, otitis media with effusion, children
Full-Text [PDF 297 kb]   (209 Downloads)    
Type of Study: case report | Subject: Oncology
Received: 2021/09/28 | Accepted: 2022/08/10 | Published: 2023/03/26
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Motamed S, Amizadeh M, Dabiri S. Langerhans cell histiocytosis presented as bilateral otitis media with effusion, a rare case report. Caspian J Intern Med 2023; 14 (2) :401-405
URL: http://caspjim.com/article-1-3135-en.html

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Volume 14, Issue 2 (Spring 2023) Back to browse issues page
Caspian Journal of Internal Medicine
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