Caspian Journal of Internal Medicine
Babol University of Medical Sciences
Tue, Mar 18, 2025
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Volume 14, Issue 2 (Spring 2023)
Caspian J Intern Med 2023, 14(2): 401-405 |
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Motamed S, Amizadeh M, Dabiri S. Langerhans cell histiocytosis presented as bilateral otitis media with effusion, a rare case report. Caspian J Intern Med 2023; 14 (2) :401-405
URL: http://caspjim.com/article-1-3135-en.html
URL: http://caspjim.com/article-1-3135-en.html
Department of Otorhinolaryngology, Afzalipour faculty of medicine, Kerman University of Medical Sciences, Kerman, Iran , amizade.m@yahoo.com
Abstract: (1645 Views)
Background: Langerhans cell histiocytosis (LCH) or histiocytosis X is considered as a rare disease that may have effect on multiple organs. The initial presentation of LCH is varied. The signs and symptoms of otologic histiocytosis can be the same as the acute or chronic infectious ear diseases. Definitive diagnosis of LCH is confirmed by biopsy and immunohistochemically staining of S-100 protein and CD1a antigen. Chemotherapy is the main mode of treatment.
Case presentation: In this report, we explained the clinical manifestation, diagnosis and treatment of a case of 15 month-old girl with diagnosed of LCH that initially presented with otitis media with effusion (OME).
Conclusion: LCH is a rare disease that presented with variable sign and symptoms and have an effect on multiple organs. LCH should be regarded in cases with recurrent ear infection without response to medical treatments. Moreover, biopsy with IHC is the gold standard of diagnosis and chemotherapy is the main form of treatment.
Case presentation: In this report, we explained the clinical manifestation, diagnosis and treatment of a case of 15 month-old girl with diagnosed of LCH that initially presented with otitis media with effusion (OME).
Conclusion: LCH is a rare disease that presented with variable sign and symptoms and have an effect on multiple organs. LCH should be regarded in cases with recurrent ear infection without response to medical treatments. Moreover, biopsy with IHC is the gold standard of diagnosis and chemotherapy is the main form of treatment.
Type of Study: case report |
Subject:
Oncology
Received: 2021/09/28 | Accepted: 2022/08/10 | Published: 2023/03/26
Received: 2021/09/28 | Accepted: 2022/08/10 | Published: 2023/03/26
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