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Caspian J Intern Med 2022, 13(4): 757-764 Back to browse issues page
Predictors and mortality of patients with delayed pulmonary embolism diagnosis: A cohort study
Hassan Aghajani , Susan Hashemi , Amirali Karimi , Somayeh Yadangi , Arash Jalali , Yaser Jenab *
Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran , yasjenab@gmail.com
Abstract:   (257 Views)
Background: Some earlier studies demonstrated an increased mortality risk attributed to delayed pulmonary embolism (PE) diagnosis. Therefore, we mainly aimed to determine the predictors of diagnostic delays and the effect of delayed diagnosis on mortality.
Methods: We prospectively studied 756 consecutive patients admitted with PE between March 2007 and September 2017. The delayed diagnosis was defined as (1) patient presenting > 7 days after onset of symptoms, (2) diagnosis takes > 24 hours upon arriving in the ED, or (3) undergoing coronary angiography before establishing PE diagnosis.
Results: A total of 127 (16.7%) patients met the delayed group’s criteria. Heart failure (OR= 2.257, 95% CI: 1.130-4.508, P= 0.021), diabetes mellitus (OR= 1.568, 95% CI: 0.996-2.469, P= 0.052), and precordial T wave inversions (OR=2.559, 95% CI: 1.649-3.970, P< 0.001) were linked to higher rates of delayed diagnosis, while hemoptysis (OR=0.254, 95% CI: 0.059-1.087, P= 0.065) and hemodynamic instability (OR= 0.434, 95% CI: 0.168-1.123, P= 0.085) negatively correlated with it. Delayed PE diagnosis did not significantly impact the overall survival during the follow-up. The unadjusted and adjusted mortality hazard ratio for delayed diagnosis were 1.198 (95% CI: 0.758- 1.894, P= 0.439) and 1.215 (95% CI: 0.762- 1.939, P=0.413), respectively. Older age, heart failure, and hemodynamic instability increased the risk of death (p<0.001).
Conclusion: Hemoptysis, hemodynamic instability, diabetes mellitus, heart failure, and T wave inversions in precordial leads were the independent predictors of delayed diagnosis. Delayed PE diagnosis did not increase the patients' mortality rates.
Keywords: Delayed diagnosis, Mortality, Pulmonary embolism, Pulmonary thromboembolism
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Type of Study: Original Article | Subject: Cardiology
Received: 2021/10/28 | Accepted: 2022/02/14 | Published: 2022/09/28
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Aghajani H, Hashemi S, Karimi A, Yadangi S, Jalali A, Jenab Y. Predictors and mortality of patients with delayed pulmonary embolism diagnosis: A cohort study. Caspian J Intern Med 2022; 13 (4) :757-764
URL: http://caspjim.com/article-1-3179-en.html


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Volume 13, Issue 4 (Autumn 2022) Back to browse issues page
Caspian Journal of Internal Medicine
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