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:: Volume 14, Issue 3 (Summer 2023) ::
Caspian J Intern Med 2023, 14(3): 586-589 Back to browse issues page
Reporting two hemoglobin J Iran cases, molecular follow-up, or is it insignificant?
Amin Solouki , Tahereh Manoochehrabadi , Farzaneh Korani , Mohammadreza Farshchi
Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran , manoochehrabadit68@gmail.com
Abstract:   (1149 Views)
Background: Hemoglobin J is one of the fast hemoglobin that has a more negative charge due to β77His→Asp substitution. Acquisition of this hemoglobin is not associated with any specific clinical sign, but the combination of this hemoglobinopathy with beta-thalassemia and other hemoglobinopathies can cause challenges.
Case Presentation: In this article, two cases with hemoglobin J are introduced; the first patient for premarital testing and the other for his fatigue. The hemoglobin electrophoresis was done by Sebia capillary zone electrophoresis and Hb J as heterozygote and homozygote were determined.
Conclusion: It must be noted that although this hemoglobinopathy is not related to any problem alone but could be confusing in combination with other hemoglobinopathies or thalassemia. In this paper, these two cases are introduced and an attempt was made to investigate the importance of molecular follow-up.

Keywords: Hemoglobinopathy, Thalassemia, Hemoglobin J, Fast hemoglobin, Molecular diagnosis
Full-Text [PDF 178 kb]   (692 Downloads)    
Type of Study: case report | Subject: Hematology
Received: 2022/01/22 | Accepted: 2022/06/8 | Published: 2023/05/29
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Solouki A, Manoochehrabadi T, Korani F, Farshchi M. Reporting two hemoglobin J Iran cases, molecular follow-up, or is it insignificant?. Caspian J Intern Med 2023; 14 (3) :586-589
URL: http://caspjim.com/article-1-3334-en.html

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Volume 14, Issue 3 (Summer 2023) Back to browse issues page
Caspian Journal of Internal Medicine
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