Caspian Journal of Internal Medicine
Babol University of Medical Sciences
Tue, Mar 18, 2025
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Volume 14, Issue 3 (Summer 2023)
Caspian J Intern Med 2023, 14(3): 567-571 |
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Omrani-Nava V, Moosazadeh M, Bahar A, Hedayatizadeh-Omran A, Ahmadi A, Alizadeh-Navaei R. Neutrophil-to-lymphocyte, platelet-to-lymphocyte and lymphocyte-to-monocyte ratios, any association with
metabolic syndrome?. Caspian J Intern Med 2023; 14 (3) :567-571
URL: http://caspjim.com/article-1-3406-en.html
URL: http://caspjim.com/article-1-3406-en.html
Versa Omrani-Nava 
, Mahmood Moosazadeh , Adeleh Bahar , Akbar Hedayatizadeh-Omran , Abdolrahim Ahmadi , Reza Alizadeh-Navaei *
, Mahmood Moosazadeh , Adeleh Bahar , Akbar Hedayatizadeh-Omran , Abdolrahim Ahmadi , Reza Alizadeh-Navaei *
Gastrointestinal Cancer Research Center, Non-Communicable Diseases Institute, Mazandaran University of Medical Science, Sari, Iran , reza_nava@gmail.com
Abstract: (1825 Views)
Background: Metabolic syndrome is a critical health concern associated with an elevated risk of chronic health problems including cardiovascular disease and diabetes. There are shreds of evidence that novel inflammatory ratios including neutrophil-to-lymphocyte, platelet-to-lymphocyte and lymphocyte-to-monocyte ratios serve as prognostic biomarkers for metabolic syndrome (MetS). This hypothesis was investigated in a cohort of the Iranian population.
Methods: selection of MetS + subjects was based on the National Cholesterol Education Program Adult Treatment Panel III criteria 3 (NCEP ATP 3). The control group consisted of participants negative for any of the five MetS criteria. Demographic and laboratory data were extracted from the Tabari cohort study.
Results: A total of 1930 subjects including 965 Mets positive and 965 MetS criteria negative participants were evaluated. Diabetes (84.8%), hypertension (48.9%), hypertriglyceridemia (81.7%), low HDL cholesterol (70.3%), and high waist circumference (78.9%) were observed in patients. There were no differences between NLR (1.66±0.71 vs. 1.69±0.72 P=0.42), LMR (11.23±3.13 vs. 11.30±11.99, P= 0.86) and PLR (113.85±68.67 vs 114.11±35.85, P=0.91) between case and control groups, respectively. Logistic regression analysis revealed no association between ratios and MetS risk even after adjusting for potential confounders including age, gender, living place, and BMI.
Conclusion: In a relatively large population from Northern Iran, no association was observed between CBC-derived inflammatory ratios and the presence of MetS.
Methods: selection of MetS + subjects was based on the National Cholesterol Education Program Adult Treatment Panel III criteria 3 (NCEP ATP 3). The control group consisted of participants negative for any of the five MetS criteria. Demographic and laboratory data were extracted from the Tabari cohort study.
Results: A total of 1930 subjects including 965 Mets positive and 965 MetS criteria negative participants were evaluated. Diabetes (84.8%), hypertension (48.9%), hypertriglyceridemia (81.7%), low HDL cholesterol (70.3%), and high waist circumference (78.9%) were observed in patients. There were no differences between NLR (1.66±0.71 vs. 1.69±0.72 P=0.42), LMR (11.23±3.13 vs. 11.30±11.99, P= 0.86) and PLR (113.85±68.67 vs 114.11±35.85, P=0.91) between case and control groups, respectively. Logistic regression analysis revealed no association between ratios and MetS risk even after adjusting for potential confounders including age, gender, living place, and BMI.
Conclusion: In a relatively large population from Northern Iran, no association was observed between CBC-derived inflammatory ratios and the presence of MetS.
Keywords: Metabolic Syndrome, Neutrophil-to-lymphocyte ratio, Platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, Iran
Type of Study: Short Communication |
Subject:
Internal
Received: 2022/03/9 | Accepted: 2022/04/27 | Published: 2023/05/19
Received: 2022/03/9 | Accepted: 2022/04/27 | Published: 2023/05/19
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