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:: Volume 14, Issue 3 (Summer 2023) ::
Caspian J Intern Med 2023, 14(3): 495-506 Back to browse issues page
HOMA estimated insulin resistance as a marker for angiographic severity of coronary artery disease in non-diabetic and non-obese patients
Mohamed Eid * , Sherif A. Sayed , Nayel A. Zaki , Amera M. F. Hamdy , Ali M. A. Altaher
Department of Internal Medicine, Faculty of Medicine, Sohag University, Sohag, Egypt , moh.eid1979@gmail.com
Abstract:   (583 Views)
Background: Insulin resistance (IR) examined by homeostasis model assessment of insulin resistance (HOMA-IR) measures increased carotid atherosclerosis risks in non-diabetic and non-obese persons. The information about the relationship between IR and coronary atherosclerosis severity among non-diabetic and non- obese population showed conflicting results. The goal of the current study was to assess the relationship that links IR and coronary artery disease (CAD) among non-diabetic and non-obese Egyptian populations.
Methods: 112 non-diabetic and non-obese patients were included in this study. These patients underwent coronary angiogram (CA) either due to acute coronary syndrome (ACS) or chronic stable angina with positive exercise tests.
Results: Our study found a strong association between HOMA-IR and Gensini score (r = 0.831, with p<0.001) in general population. The HOMA-IR was the most influential independent predictor for the presence of extensive coronary atherosclerosis. Non-diabetic and non-obese people carrying the risk of developing the three-vessel disease (3VD) may be identified with a HOMA-IR score of over 5.9 according to the ROC curve analysis with a sensitivity of 67.7%.
Conclusion: IR that developes in non-diabetic non-obese individuals coincides with more severe and more outspread CAD. In non-diabetic non-obese populations who need a CA, a single HOMA-IR value is higher than 5.9 may imply an elevated risk for clinically significant CAD. As insulin resistance is a reversible process, risk stratifications of CAD in non-diabetic non-obese populations could include HOMA-IR as one of its parameters.

Keywords: Coronary Artery Disease, Coronary Atherosclerosis, HOMA estimated Insulin resistance.
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Type of Study: Original Article | Subject: Internal
Received: 2022/04/19 | Accepted: 2023/05/9 | Published: 2023/05/9
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Eid M, A. Sayed S, A. Zaki N, M. F. Hamdy A, M. A. Altaher A. HOMA estimated insulin resistance as a marker for angiographic severity of coronary artery disease in non-diabetic and non-obese patients. Caspian J Intern Med 2023; 14 (3) :495-506
URL: http://caspjim.com/article-1-3452-en.html

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Volume 14, Issue 3 (Summer 2023) Back to browse issues page
Caspian Journal of Internal Medicine
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