Caspian Journal of Internal Medicine
Babol University of Medical Sciences
Fri, Oct 31, 2025
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Volume 15, Issue 2 (Spring 2024)
Caspian J Intern Med 2024, 15(2): 340-346 |
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AkbariRad M, Mazloum Khorasani Z, Beizae B, Ayatollahi H, Emadzadeh M, Sarabi M, et al . Effect of selenium on anti-Tg antibody in patients with autoimmune hypothyroidism: A randomized controlled trial. Caspian J Intern Med 2024; 15 (2) :340-346
URL: http://caspjim.com/article-1-3584-en.html
URL: http://caspjim.com/article-1-3584-en.html
Mina AkbariRad 
, Zahra Mazloum Khorasani * , Behnam Beizae , Hossein Ayatollahi , Maryam Emadzadeh , Mehrdad Sarabi , Nikoo Saeedi , Negar Nekooei
, Zahra Mazloum Khorasani * , Behnam Beizae , Hossein Ayatollahi , Maryam Emadzadeh , Mehrdad Sarabi , Nikoo Saeedi , Negar Nekooei
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran , MazloumZ@mums.ac.ir
Abstract: (2437 Views)
Background: The current study intends to assess the impact of oral selenium intake on anti-Tg antibody in individuals with autoimmune hypothyroidism.
Methods: In this double-blinded randomized controlled trial, two groups of 72 autoimmune hypothyroid patients were randomly assigned; One group received levothyroxine (LT4) and oral selenium and the other group was given placebo with LT4. Anti-Tg antibody, free T4, anti-TPO antibody, and TSH were identified in both groups before the treatment and also 3 months after treatment and analysis of data was done by SPSS software.
Results: After the intervention, the average amount of anti-Tg antibody decreased in both of the groups, and this decrease was noticeably greater in the intervention group (P = 0.03). In the intervention group, the TSH level decreased after the intervention (p < 0.05), and the free T4 level increased after the intervention (p < 0.05); the changes in these two variables were statistically significant.
Conclusion: Consumption of selenium, compared to placebo, in patients with autoimmune hypothyroidism drastically reduces the level of anti-Tg antibody, and it significantly increases the free T4 level. Also, there is a greater decrease in the level of TSH compared to the control group.
Methods: In this double-blinded randomized controlled trial, two groups of 72 autoimmune hypothyroid patients were randomly assigned; One group received levothyroxine (LT4) and oral selenium and the other group was given placebo with LT4. Anti-Tg antibody, free T4, anti-TPO antibody, and TSH were identified in both groups before the treatment and also 3 months after treatment and analysis of data was done by SPSS software.
Results: After the intervention, the average amount of anti-Tg antibody decreased in both of the groups, and this decrease was noticeably greater in the intervention group (P = 0.03). In the intervention group, the TSH level decreased after the intervention (p < 0.05), and the free T4 level increased after the intervention (p < 0.05); the changes in these two variables were statistically significant.
Conclusion: Consumption of selenium, compared to placebo, in patients with autoimmune hypothyroidism drastically reduces the level of anti-Tg antibody, and it significantly increases the free T4 level. Also, there is a greater decrease in the level of TSH compared to the control group.
Policy Brief: Original Article |
Subject:
Endocrinology
Received: 2022/07/19 | Accepted: 2024/02/24 | Published: 2024/02/24
Received: 2022/07/19 | Accepted: 2024/02/24 | Published: 2024/02/24
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