Naser Moghadasi A, Rezaeimanesh N. Beyond the division of multiple sclerosis into different subgroups: The Concept of Connectomopathy. Caspian J Intern Med 2024; 15 (3) :370-373
URL:
http://caspjim.com/article-1-3704-fa.html
چکیده: (1123 مشاهده)
Multiple Sclerosis (MS) pathophysiologically is a dynamic and progressive disease that involves all parts of central nervous system. This widespread involvement of the CNS has paved the way for proposing a new theory in MS in which MS is considered as a connectomopathy. Connectomopathy is a new concept describing the diseases in which not only the brain connectome is completely and extensively damaged, but the defective connectome itself can also become a breeding ground for the disease’s progression. Connectomopathy provides a dynamic picture of MS. Since each person’s connectome is unique to him/herself, so MS patients’ connectomopathy varies from one to another. This variety not only challenges the classification of MS into different phenotypes, but also emphasizes the need for providing a personalized approach for the treatment of these patients.
نوع مطالعه:
Review Article |
موضوع مقاله:
Neurology دریافت: 1401/7/25 | پذیرش: 1402/7/30 | انتشار: 1403/2/12