Volume 15, Issue 3 (Summer 2024)                   Caspian J Intern Med 2024, 15(3): 370-373 | Back to browse issues page

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Naser Moghadasi A, Rezaeimanesh N. Beyond the division of multiple sclerosis into different subgroups: The Concept of Connectomopathy. Caspian J Intern Med 2024; 15 (3) :370-373
URL: http://caspjim.com/article-1-3704-en.html
Beyond the division of multiple sclerosis into different subgroups: The Concept of Connectomopathy
Abdorreza Naser Moghadasi * , Nasim Rezaeimanesh
Multiple Sclerosis Research Center, Neuroscience institute, Tehran University of Medical Sciences, Tehran, Iran , abdorrezamoghadasi@gmail.com
Abstract:   (1128 Views)
Multiple Sclerosis (MS) pathophysiologically is a dynamic and progressive disease that involves all parts of central nervous system. This widespread involvement of the CNS has paved the way for proposing a new theory in MS in which MS is considered as a connectomopathy. Connectomopathy is a new concept describing the diseases in which not only the brain connectome is completely and extensively damaged, but the defective connectome itself can also become a breeding ground for the disease’s progression. Connectomopathy provides a dynamic picture of MS. Since each person’s connectome is unique to him/herself, so MS patients’ connectomopathy varies from one to another. This variety not only challenges the classification of MS into different phenotypes, but also emphasizes the need for providing a personalized approach for the treatment of these patients.
 
Keywords: Multiple Sclerosis, Connectomopathy, MS phenotypes
Full-Text [PDF 385 kb]   (346 Downloads)    
Type of Study: Review Article | Subject: Neurology
Received: 2022/10/17 | Accepted: 2023/10/22 | Published: 2024/05/1
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