Volume 6, Issue 2 (4-2015)                   Caspian J Intern Med 2015, 6(2): 62-66 | Back to browse issues page

XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Fotouk-kiai M, Hoseini S R, Meftah N, Ghadimi R, Bijani A, Noreddini H, et al . Relationship between Helicobacter pylori infection (HP) and bone mineral density (BMD) in elderly people. Caspian J Intern Med 2015; 6 (2) :62-66
URL: http://caspjim.com/article-1-375-en.html
Department of Internal Medicine, Babol University of Medical Sciences, Babol, Iran , javad.shokry@gmail.com
Abstract:   (8958 Views)

  Background: Low bone mass is a frequent complication of chronic inflammatory disease. The pathogenesis of osteoporosis in chronic inflammatory disease may be secondary to releases of cytokines such as TNF-a and IL6. Chronic gastritis due to helicobacter pylori (HP) infection may lead to decreased bone mineral density (BMD) and predispose patients to osteoporosis. The objective of this study was to determine the BMD status in HP positive patients with gastritis versus HP negative cases. 

Methods: In this cross-sectional study, we enrolled 967 participants aged 60 years old and more from Amirkola Health Study Ageing Project. Seven-hundred and fifty eight HP positive and 209 HP negative patients were analyzed. BMD was measured by dual-energy x-ray absorptiometry (DXA) method in the spine and femoral neck in all participants. 

Results: The mean age in HP+ and HP- negative patients was 68.3±6.8 and 69.3±7.4 years, respectively. BMD g/cm2 in the spine and femoral neck did not differ between the two groups (P=0.19 and 0.22 respectively). The prevalence of osteoporosis did not also differ across the two groups as well. There was no relationship between the level of antibodies against HP and BMD.

Conclusion: According to the findings of this study, H. pylori infection is not associated with BMD changes in the elderly population.

 
Full-Text [PDF 421 kb]   (2520 Downloads)    
Type of Study: Original Article | Subject: Gastroentrology
Received: 2014/08/7 | Accepted: 2015/02/14 | Published: 2015/03/15

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2025 CC BY-NC 4.0 | Caspian Journal of Internal Medicine

Designed & Developed by: Yektaweb