Volume 15, Issue 1 (Winter 2024)                   Caspian J Intern Med 2024, 15(1): 199-201 | Back to browse issues page

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Mirsafaee L, Dehghani Firouzabadi M, Parkhideh S, Vahidnezhad H, Dehghani Firouzabadi F, Arab M, et al . Correlation between Melphalan chemotherapy with longitudinal global strain indices of the left ventricle in multiple myeloma patients: a velocity vector imaging (VVI) echocardiography study. Caspian J Intern Med 2024; 15 (1) :199-201
URL: http://caspjim.com/article-1-3763-en.html
Correlation between Melphalan chemotherapy with longitudinal global strain indices of the left ventricle in multiple myeloma patients: a velocity vector imaging (VVI) echocardiography study
Liaosadat Mirsafaee , Mohammad Dehghani Firouzabadi , Sayeh Parkhideh , Hassan Vahidnezhad , Fatemeh Dehghani Firouzabadi , Maryam Arab , David M. Yousem , Mersedeh Karvandi *
Cardivascular Research Institute of Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , mr.karvandi@sbmu.ac.ir
Abstract:   (1076 Views)
Multiple myeloma (MM) is characterized by the neoplastic proliferation of plasma cells, leading to the production of monoclonal immunoglobulins. High-dose chemotherapy with autologous stem cell transplant has been used in the treatment of patients with MM (1). Melphalan (L-phenylalanine nitrogen mustard) is one of the most effective chemotherapeutic drugs in the treatment of MM (2). The side effects of melphalan include anemia, nausea, vomiting, allergic reactions, oral ulcers, nephrotoxicity, and arrhythmia at high doses (3). The effect of this drug on cardiac mechanics and heart damage is not well established, as previous studies have only focused on the electrocardiographic and metabolic effects of this drug.
Keywords: Cardiotoxicity, Melphalan, Multiple Myeloma, Velocity Vector Imaging Echocardiography
Full-Text [PDF 379 kb]   (388 Downloads)    
Type of Study: Letter to Editor | Subject: Cardiology
Received: 2022/11/22 | Accepted: 2023/03/18 | Published: 2024/01/9
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