Caspian Journal of Internal Medicine
Babol University of Medical Sciences
Tue, Nov 4, 2025
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Volume 15, Issue 2 (Spring 2024)
Caspian J Intern Med 2024, 15(2): 215-227 |
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Kardan R, Hemmati J, Nazari M, Ahmadi A, Asghari B, Azizi M, et al . Novel therapeutic strategy for obesity through the gut microbiota-brain axis: A review article. Caspian J Intern Med 2024; 15 (2) :215-227
URL: http://caspjim.com/article-1-3831-en.html
URL: http://caspjim.com/article-1-3831-en.html
Romina Kardan 
, Jaber Hemmati , Mohsen Nazari , Amjad Ahmadi , Babak Asghari , Mehdi Azizi , Mansoor Khaledi , Mohammad Reza Arabestani *
, Jaber Hemmati , Mohsen Nazari , Amjad Ahmadi , Babak Asghari , Mehdi Azizi , Mansoor Khaledi , Mohammad Reza Arabestani *
Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran , rezaeeit93@gmail.com
Abstract: (2628 Views)
Background: The interaction between commensal bacteria and the host is essential for health and the gut microbiota-brain axis plays a vital role in this regard. Obesity as a medical problem not only affect the health of the individuals, but also the economic and social aspects of communities. The presence of any dysbiosis in the composition of the gut microbiota disrupts in the gut microbiota-brain axis, which in turn leads to an increase in appetite and then obesity. Because common treatments for obesity have several drawbacks, the use of microbiota-based therapy in addition to treatment and prevention of obesity can have other numerous benefits for the individual. In this review, we intend to investigate the relationship between obesity and the gut microbiota-brain axis as well as novel treatment strategies based on this axis with an emphasis on gut microbiota.
Keywords: Gut–brain axis, Obesity, Gut microbiota, Probiotic, Prebiotic, Fecal Microbiota transplantation.
Policy Brief: Review Article |
Subject:
Gastroentrology
Received: 2023/01/19 | Accepted: 2024/02/20 | Published: 2024/02/2
Received: 2023/01/19 | Accepted: 2024/02/20 | Published: 2024/02/2
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