Caspian Journal of Internal Medicine
Babol University of Medical Sciences
چهارشنبه 29 اسفند 1403
[Archive]
دوره 15، شماره 2 - ( 11-1402 )
جلد 15 شماره 2 صفحات 272-266 |
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Farazmand T, Rahbarian R, Jalali M, Ghahremani A, Razi A, Namdar Ahmadabad H. Vitamin D levels in non-pregnant women with a history of recurrent pregnancy loss with and without autoantibodiesdies. Caspian J Intern Med 2024; 15 (2) :266-272
URL: http://caspjim.com/article-1-3840-fa.html
URL: http://caspjim.com/article-1-3840-fa.html
Vitamin D levels in non-pregnant women with a history of recurrent pregnancy loss with and without autoantibodiesdies. . 1402; 15 (2) :266-272
چکیده: (1140 مشاهده)
Background:The objective of this study was to compare the levels of vitamin D in non-pregnant women with a history of recurrent pregnancy loss (RPL) who were seropositive or seronegative for autoantibodies (autoAbs).
Methods: The study examined 58 RPL patients with autoAbs (ANA, anti-TPO, or APAs), 34 RPL patients without autoAbs, and 58 healthy women with prior successful pregnancies and without autoantibodies. The levels of 25 (OH) D were measured using the sandwich ELISA technique.
Results:Our results showed insufficient serum 25(OH) D levels in study groups, with significantly lower levels observed in RPL patients with or without autoAbs compared to healthy women (P=0.0006). In addition, RPL patients with autoAbs had significantly lower 25(OH) D levels compared to RPL patients without autoAbs. We also found that serum levels of 25(OH) D in RPL patients with autoAbs were significantly lower than in RPL patients without autoAbs (20.51 ± 1.15 ng/ml Vs. 23.69 ± 0.74 ng/ml, P=0.0356). Further analysis indicated that RPL patients who were positive for ANA, and APAs, except anti-TPO, had significantly lower than 25(OH)D serum levels than RPL patients without autoAbs.
Conclusion: These findings suggest that RPL patients, especially those with APAs or ANA, have lower vitamin D levels compared to healthy women. This may indicate a link between maternal immune dysregulation due to vitamin D deficiency and the presence of autoantibodies in RPL.
Methods: The study examined 58 RPL patients with autoAbs (ANA, anti-TPO, or APAs), 34 RPL patients without autoAbs, and 58 healthy women with prior successful pregnancies and without autoantibodies. The levels of 25 (OH) D were measured using the sandwich ELISA technique.
Results:Our results showed insufficient serum 25(OH) D levels in study groups, with significantly lower levels observed in RPL patients with or without autoAbs compared to healthy women (P=0.0006). In addition, RPL patients with autoAbs had significantly lower 25(OH) D levels compared to RPL patients without autoAbs. We also found that serum levels of 25(OH) D in RPL patients with autoAbs were significantly lower than in RPL patients without autoAbs (20.51 ± 1.15 ng/ml Vs. 23.69 ± 0.74 ng/ml, P=0.0356). Further analysis indicated that RPL patients who were positive for ANA, and APAs, except anti-TPO, had significantly lower than 25(OH)D serum levels than RPL patients without autoAbs.
Conclusion: These findings suggest that RPL patients, especially those with APAs or ANA, have lower vitamin D levels compared to healthy women. This may indicate a link between maternal immune dysregulation due to vitamin D deficiency and the presence of autoantibodies in RPL.
نوع مطالعه: Original Article |
موضوع مقاله:
Obstetrics & Gynicology
دریافت: 1401/11/8 | پذیرش: 1402/11/13 | انتشار: 1402/11/13
دریافت: 1401/11/8 | پذیرش: 1402/11/13 | انتشار: 1402/11/13
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