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:: Volume 15, Issue 2 (Spring 2024) ::
Caspian J Intern Med 2024, 15(2): 266-272 Back to browse issues page
Vitamin D levels in non-pregnant women with a history of recurrent pregnancy loss with and without autoantibodiesdies
Tooba Farazmand , Raheleh Rahbarian , Mitra Jalali , Amirali Ghahremani , Abdollah Razi , Hasan Namdar Ahmadabad
Vector-borne Diseases Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran , namdar360@gmail.com
Abstract:   (296 Views)
Background:The objective of this study was to compare the levels of vitamin D in non-pregnant women with a history of recurrent pregnancy loss (RPL) who were seropositive or seronegative for autoantibodies (autoAbs).
Methods: The study examined 58 RPL patients with autoAbs (ANA, anti-TPO, or APAs), 34 RPL patients without autoAbs, and 58 healthy women with prior successful pregnancies and without autoantibodies. The levels of 25 (OH) D were measured using the sandwich ELISA technique.
Results:Our results showed insufficient serum 25(OH) D levels in study groups, with significantly lower levels observed in RPL patients with or without autoAbs compared to healthy women (P=0.0006).  In addition, RPL patients with autoAbs had significantly lower 25(OH) D levels compared to RPL patients without autoAbs. We also found that serum levels of 25(OH) D in RPL patients with autoAbs were significantly lower than in RPL patients without autoAbs (20.51 ± 1.15 ng/ml Vs. 23.69 ± 0.74 ng/ml, P=0.0356). Further analysis indicated that RPL patients who were positive for ANA, and APAs, except anti-TPO, had significantly lower than 25(OH)D serum levels than RPL patients without autoAbs.
Conclusion: These findings suggest that RPL patients, especially those with APAs or ANA, have lower vitamin D levels compared to healthy women. This may indicate a link between maternal immune dysregulation due to vitamin D deficiency and the presence of autoantibodies in RPL.

Keywords: Vitamin D, Recurrent pregnancy loss, antinuclear antibody, Antiphospholipid antibody, Anti-thyroid peroxidase.
Full-Text [PDF 546 kb]   (145 Downloads)    
Type of Study: Original Article | Subject: Obstetrics & Gynicology
Received: 2023/01/28 | Accepted: 2024/02/2 | Published: 2024/02/2
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Farazmand T, Rahbarian R, Jalali M, Ghahremani A, Razi A, Namdar Ahmadabad H. Vitamin D levels in non-pregnant women with a history of recurrent pregnancy loss with and without autoantibodiesdies. Caspian J Intern Med 2024; 15 (2) :266-272
URL: http://caspjim.com/article-1-3840-en.html

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Volume 15, Issue 2 (Spring 2024) Back to browse issues page
Caspian Journal of Internal Medicine
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