Volume 16, Issue 2 (Spring 2025)                   Caspian J Intern Med 2025, 16(2): 328-335 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Kountouras J, Polyzos S, Zavos C, Kazakos E, Tzitiridou-Chatzopoulou M, Chatzopoulos D, et al . Relationship Mitral valve prolapse syndrome and duodenal ulcer disease with concomitant autonomic dysfunction. Caspian J Intern Med 2025; 16 (2) :328-335
URL: http://caspjim.com/article-1-4070-en.html
Department of Internal Medicine, Second Medical Clinic, Ippokration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Macedonia, Greece , jannis@auth.gr
Abstract:   (237 Views)

Background: There is no evidence regarding the crucial topic of possible correlation between duodenal ulcer disease and mitral valve prolapse syndrome. We herein investigated the potential relationship between these two disorders.
Methods: Eighty-three hospitalized patients with active duodenal ulcer disease were compared with 31 healthy controls for the presence of mitral valve prolapse syndrome. All participants underwent cardiac examination and echocardiography. Heart rate, systolic and diastolic pressures were estimated in supine baseline and standing positions.
Results: Echocardiographic mitral valve prolapse was present in 36 (43.37%) of the patients and only in 1 (3%) of controls (P=0.001). Auscultatory findings of systolic murmurs (50% vs. 4%, respectively; P=0.001) and symptoms related to the cardiovascular system (i.e., chest pain: 75% vs. 30%, respectively; P=0.001) were more common in patients with mitral valve prolapse than those without it. Heart rate was lesser in patients with mitral valve prolapse in supine location (71.00±1.73 vs. 76.10±1.66, respectively; P=0.04), and was higher in the upright location in patients than those without mitral valve prolapse (91.54±2.73 vs. 83.42±2.71, respectively; P=0.04) and in normal controls (91.54±2.73 vs. 84.06±2.02, respectively; P=0.03). Moreover, blood group O and male gender were more common among the patients with mitral valve prolapse, compared to normal controls (67% vs. 39%, respectively; P=0.03, and 61% vs. 35%; P=0.05, respectively).
Conclusion: Our findings suggest a clinical and genetic relationship between active duodenal ulcer and mitral valve prolapse syndrome connected with autonomic dysfunction. Further studies are warranted to confirm this crucial topic.

 

Full-Text [PDF 477 kb]   (21 Downloads)    
Type of Study: Original Article | Subject: Gastroentrology
Received: 2023/09/7 | Accepted: 2024/03/17 | Published: 2025/03/21

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2025 CC BY-NC 4.0 | Caspian Journal of Internal Medicine

Designed & Developed by: Yektaweb