Caspian Journal of Internal Medicine
Babol University of Medical Sciences
Fri, Feb 21, 2025
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Volume 16, Issue 1 (Winter 2025)
Caspian J Intern Med 2025, 16(1): 47-57 |
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Faramarzpour M, Mohammad Hosseiniazar M, Hooshmand Gharabagh L. Assessment of Relationship between Non-alcoholic Fatty Liver Disease and LV Diastolic Dysfunction in Patients with Type 2 Diabetes Mellitus. Caspian J Intern Med 2025; 16 (1) :47-57
URL: http://caspjim.com/article-1-4102-en.html
URL: http://caspjim.com/article-1-4102-en.html
Department of Internal Medicine, School of Medicine, Imam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran , Laya.hooshmand58@gmail.com
Abstract: (744 Views)
Background: To date, the clinical implications of the long-lasting non-alcoholic fatty liver disease (NAFLD) such as the left ventricular diastolic dysfunction (LVDD) in the course of type 2 diabetes mellitus (T2DM) are yet to be determined. The main aim of this study was to investigate the correlation between NAFLD and early LVDD progression along with demographic characteristics.
Methods: This cross-sectional study was performed on ninety consecutive diabetic outpatients referred to the endocrinology clinic. Demographic data were collected using a designed checklist. Ultrasound imaging was performed to assess the fatty liver condition. To assess LV diastolic function, echocardiography was performed, using a trans-thoracic tissue Doppler echocardiography.
Results: The results showed that the majority of participants were females (61.1%). The fasting blood glucose (FBG, mg/dl) level was 174.65 ±51.1. Also, the mean body mass index (BMI) was 28.92±4.19, which was significantly associated with NAFLD. It has been also estimated that 76.7% and 81.1% of diabetic patients had NAFLD and simultaneous LVDD, respectively. However, the statistical results did not show a significant association between non-progressive NAFLD and LVDD (p<0.05).
Conclusion: There was no correlation between NAFLD and LVDD progression. However, timely evaluation of LVDD in T2DM outpatients with NAFLD can strongly help to prevent possible cardiomyopathy in high-risk populations.
Methods: This cross-sectional study was performed on ninety consecutive diabetic outpatients referred to the endocrinology clinic. Demographic data were collected using a designed checklist. Ultrasound imaging was performed to assess the fatty liver condition. To assess LV diastolic function, echocardiography was performed, using a trans-thoracic tissue Doppler echocardiography.
Results: The results showed that the majority of participants were females (61.1%). The fasting blood glucose (FBG, mg/dl) level was 174.65 ±51.1. Also, the mean body mass index (BMI) was 28.92±4.19, which was significantly associated with NAFLD. It has been also estimated that 76.7% and 81.1% of diabetic patients had NAFLD and simultaneous LVDD, respectively. However, the statistical results did not show a significant association between non-progressive NAFLD and LVDD (p<0.05).
Conclusion: There was no correlation between NAFLD and LVDD progression. However, timely evaluation of LVDD in T2DM outpatients with NAFLD can strongly help to prevent possible cardiomyopathy in high-risk populations.
Keywords: Early Diagnosis, Ventricular Dysfunction, Fatty Liver, Type 2 Diabetes Mellitus, Risk factors
Type of Study: Original Article |
Subject:
Internal
Received: 2023/10/2 | Accepted: 2024/01/13 | Published: 2025/10/26
Received: 2023/10/2 | Accepted: 2024/01/13 | Published: 2025/10/26
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