دوره 6، شماره 4 - ( 7-1394 )                   جلد 6 شماره 4 صفحات 200-196 | برگشت به فهرست نسخه ها

XML English Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Khadir F, Pouramir M, Joorsaraie G, Feizi F, Sorkhi H, Yousefi F. A Study of arbutin protective effect on cyclosporin A-induced oxidative damage. Caspian J Intern Med 2015; 6 (4) :196-200
URL: http://caspjim.com/article-1-429-fa.html
A Study of arbutin protective effect on cyclosporin A-induced oxidative damage. . 1394; 6 (4) :196-200

URL: http://caspjim.com/article-1-429-fa.html


چکیده:   (9111 مشاهده)

 Background: Cyclosporine A (CsA) is a potent immunosuppressant drug with therapeutic and toxic actions. The use of CsA is limited by its toxicity. Several researchers had proposed that oxidative stress could play an important role in CsA-induced toxicity. Arbutin has recently been shown to possess antioxidative and free radical scavenging abilities.The present study was designed to investigate the in vivo effects of arbutin on lipid peroxidation and antioxidant capacity in the serum of cyclosporine treated rats.

 Methods: Adult male Wistar rats were divided into six groups (n=8/group): (I) control (no CsA and arbutin administration), (II and III) were treated subcutaneously (Sc) with arbutin (50,100 mg/kg/bw), respectively, (IV) administered CsA (25 mg/kg/bw) intraperitoneally (IP), (V and VI) received the combination of CsA (25 mg/kg/bw) i.p and arbutin (50,100 mg/kg/bw) Sc daily, respectively. At the end of the treatment (after3 weeks), serum lipid peroxidation was measured by thiobarbituric acid-reacting substances (TBARS) and serum total antioxidant capacity (ferric reducing ability of plasma [FRAP]) was assayed based on spectrophotometric method.

 Results: TBARS had been significantly increased by CsA administration compared with control rats. Arbutin (50mg/kg/bw) completely prevented this effect, but arbutin (100 mg/kg/bw) alone or in combination with CsA significantly increased lipid peroxidation compared with controls.

 Conclusion: Our data indicate that arbutin (50mg/kg/bw) had protective effect in the CsA-induced toxicity but high concentration of arbutin (100mg/kg/bw) showed meaningful oxidative and lipoperoxidative effects.

 

متن کامل [PDF 333 kb]   (2382 دریافت)    
نوع مطالعه: Original Article | موضوع مقاله: Biochimestry
دریافت: 1393/8/11 | پذیرش: 1394/2/20 | انتشار: 1394/6/17

ارسال نظر درباره این مقاله : نام کاربری یا پست الکترونیک شما:
CAPTCHA

بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.

کلیه حقوق این وب سایت متعلق به می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2025 CC BY-NC 4.0 | Caspian Journal of Internal Medicine

Designed & Developed by : Yektaweb