Diabetes research Center, Mazandaran University of Medical Sciences, Sari, Iran , zr_akha@yahoo.com
Abstract: (10801 Views)
Background: Levothyroxine is commonly used in the treatment of
patients with hypothyroidism. Levothyroxine is often administered in the
morning, on an empty stomach, to increase its absorption. However, many
patients have trouble for taking levothyroxine in the morning. The aim of this
study was to evaluate the effect of changing administration time of
levothyroxine from before breakfast to before dinner on serum levels of TSH and
T4.
Methods: Fifty hypothyroidism patients aged 18-75 years old
were included in the study and randomly divided into two groups. Each group
received two tablets per day blindly (one
levothyroxine tablet and one placebo tablet) before breakfast and before
dinner. After two months, the administration time for the tablets was changed
for each group, and the new schedule was continued for a further two-month
period. The serum TSH and T4 levels were measured before and after treatment in
each group.
Results: Changing the levothyroxine administration time,
resulted in 1.47±0.51 µIU/mL increase in TSH level (P=0.001) and 0.35±1.05µg/dL
decrease in T4 level (P=0.3).
Conclusion: Changing the levothyroxine administration time from before
breakfast to before dinner minimally reduced the therapeutic efficacy of
levothyroxine.
Ala S, Akha O, Kashi Z, Asgarirad H, Bahar A, Sasanpoor N. Dose levotyroxine consumption in hypothyroid patients before dinner change the levels of TSH and T4? . Caspian J Intern Med 2015; 6 (3) :134-140 URL: http://caspjim.com/article-1-464-en.html