Caspian Journal of Internal Medicine
Babol University of Medical Sciences
Thu, Jan 8, 2026
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Volume 17, Issue 1 (Winter 2026)
Caspian J Intern Med 2026, 17(1): 74-81 |
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Ethics code: IR.GMU.REC.1401.182
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Tavakolizadeh A, Mohammadzadeh H, Mokhtari A M, Karami Y, Khorasani M, Saadatian Z, et al . Angiotensin-converting enzyme gene insertion/deletion polymorphism and its impact on response to azithromycin and doxycycline treatment in acne vulgaris patients. Caspian J Intern Med 2026; 17 (1) :74-81
URL: http://caspjim.com/article-1-4854-en.html
URL: http://caspjim.com/article-1-4854-en.html
Alireza Tavakolizadeh 
, Hamideh Mohammadzadeh * , Ali Mohammad Mokhtari , Younes Karami , Milad Khorasani , Zahra Saadatian , Zahra Rajabzadeh , Mohammad Amin Momeni-Moghaddam
, Hamideh Mohammadzadeh * , Ali Mohammad Mokhtari , Younes Karami , Milad Khorasani , Zahra Saadatian , Zahra Rajabzadeh , Mohammad Amin Momeni-Moghaddam
Department of Dermatology, School of Medicine, Gonabad University of Medical Sciences,Gonabad, Iran , Mohammadzadeh.hamideh@yahoo.com
Abstract: (56 Views)
Background: Acne vulgaris (AV) is a common inflammatory skin disorder. Systemic treatments like azithromycin and doxycycline are frequently used. The Angiotensin-Converting Enzyme (ACE) has been implicated in inflammation and skin diseases. This study investigated the association between ACE I/D polymorphism and therapeutic response to azithromycin versus doxycycline in moderate AV.
Methods: This clinical trial enrolled 54 moderate AV patients divided equally into two groups: one received 100 mg/day doxycycline, the other 250 mg/day azithromycin for 3 months. DNA was extracted via salting-out method, and ACE I/D polymorphism was analyzed by PCR and electrophoresis. Treatment efficacy was assessed using Michelson’s acne score and standardized photography. Post-treatment, genotype-phenotype correlations were evaluated.
Results: The doxycycline group showed significantly higher recovery rates (59.3%) compared to azithromycin (18.5%) (p<0.001). However, no statistically significant association was observed between improvement percentages and genotypes in either the doxycycline ((P = 0.567) or azithromycin (P = 0.533) groups.
Conclusion: Doxycycline was significantly more effective than azithromycin for moderate AV. However, no significant association was found between ACE I/D polymorphism and treatment response for either antibiotic. These findings guide therapeutic selection while suggesting that ACE genotyping may not predict treatment response in moderate AV.
Methods: This clinical trial enrolled 54 moderate AV patients divided equally into two groups: one received 100 mg/day doxycycline, the other 250 mg/day azithromycin for 3 months. DNA was extracted via salting-out method, and ACE I/D polymorphism was analyzed by PCR and electrophoresis. Treatment efficacy was assessed using Michelson’s acne score and standardized photography. Post-treatment, genotype-phenotype correlations were evaluated.
Results: The doxycycline group showed significantly higher recovery rates (59.3%) compared to azithromycin (18.5%) (p<0.001). However, no statistically significant association was observed between improvement percentages and genotypes in either the doxycycline ((P = 0.567) or azithromycin (P = 0.533) groups.
Conclusion: Doxycycline was significantly more effective than azithromycin for moderate AV. However, no significant association was found between ACE I/D polymorphism and treatment response for either antibiotic. These findings guide therapeutic selection while suggesting that ACE genotyping may not predict treatment response in moderate AV.
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Subject:
Dermathology
Received: 2025/07/27 | Accepted: 2025/10/12 | Published: 2026/01/11
Received: 2025/07/27 | Accepted: 2025/10/12 | Published: 2026/01/11
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