Antioxidant Therapy for Endometriosis Pain: Current Evidence and Policy Implications

Esmaeilzadeh, Sedighe; Agajani Delavar, Moloud; Mirabi, Parvaneh

doi:10.22088/cjim.16.4.814

Volume 16, Issue 4 (Autumn 2025) Caspian J Intern Med 2025, 16(4): 814-818 | Back to browse issues page

‎ 10.22088/cjim.16.4.814

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Esmaeilzadeh S, Agajani Delavar M, Mirabi P. Antioxidant Therapy for Endometriosis Pain: Current Evidence and Policy Implications. Caspian J Intern Med 2025; 16 (4) :814-818
URL: http://caspjim.com/article-1-4861-en.html

Antioxidant Therapy for Endometriosis Pain: Current Evidence and Policy Implications

Sedighe Esmaeilzadeh

, Moloud Agajani Delavar

, Parvaneh Mirabi ^*

Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. , parvaneh_mirabi@yahoo.com

Abstract: (3 Views)

Antioxidant therapies, accessible and cost-effective, present a viable strategy for enhancing health equity in endometriosis management while potentially decreasing dependence on expensive treatments. By addressing oxidative stress, a central factor in disease advancement compounds like vitamins C, E, and D, N-acetylcysteine, curcumin, resveratrol, and melatonin offer non-hormonal avenues for symptom relief. Evidence indicates pain reduction, notably with melatonin, yet studies are small, varied, and inconclusive regarding lesion reduction. Policy recommendations emphasize funding robust multicenter trials, cautiously integrating antioxidants into clinical guidelines, educating clinicians, and empowering patients through awareness campaigns. Their low cost and safety profile make antioxidants a compelling adjunct, aligning with patient needs and promoting access in resource-limited settings. Targeted investment in biomarker research could further refine personalized treatment, improving outcomes for millions living with this chronic condition.

Keywords: Endometriosis Pain, antioxidant, policy brief

Full-Text [PDF 335 kb] (4 Downloads)

Policy Brief: Review Article | Subject: Obstetrics & Gynicology
Received: 2025/08/1 | Accepted: 2025/10/27 | Published: 2025/09/14