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:: Volume 11, Issue 4 (6-2020) ::
Caspian J Intern Med 2020, 11(4): 385-392 Back to browse issues page
Serum Levels of Zinc, Copper, Selenium and Glutathione Peroxidase in Different Groups of Colorectal Cancer Patients
Ghassan Sulaiman , Raghad Al-ansari , Abdulnasser AL-Gebori
Applied Chemistry Division, Applied Science Department, University of Technology, Baghdad, Iraq , gmsbiotech@hotmail.com
Abstract:   (362 Views)
Background: Colorectal cancer (CRC) is considered the fourth type of cancer that causes death in the world. Changes in levels of Zinc (Zn), Copper (Cu), and Selenium (Se) as well as low glutathione peroxidase (GPx) activity can lead to CRC and this study was aimed to evaluate their possible use as diagnostic markers.
Methods: CRC patients (n=90) were divided into three groups; newly diagnosed, before surgery, and after surgery. These groups were compared to healthy subjects (n=30); the mean age ±SD was 50.63±9.26 and 49.97 ±10.85 for CRC patients and healthy subjects, respectively. Biochemical study for serum levels of Zn and Cu were measured by FAAS, Se was measured by HGAAS, and ELISA for GPx.
Results: Zn, Cu, Se and GPx were significantly lower in all CRC patient groups, except for the after surgery group which showed no differences for Zn and GPx as compared to the healthy subjects. Positive correlations were found between Se and Zn and between Se and GPx (r = 0.71, r = 0.42; P < 0.01, respectively) in all CRC patient groups. A receiver operating characteristic (ROC) curve analysis applied for the newly diagnostic group showed that all parameters can be used as diagnostic markers for CRC.
Conclusion: The present results conclude that Zn, Cu Se, and GPx can be used as diagnostic markers for CRC, where the decrease of these parameters may be associated with an increased risk of CRC and as indicators of the response to therapy.
Keywords: Colorectal cancer, Zn, Cu, Se, GPx, Serum
     
Type of Study: Original Article | Subject: Biochimestry
Received: 2019/09/15 | Accepted: 2020/02/16 | Published: 2017/07/15
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Sulaiman G, Al-ansari R, AL-Gebori A. Serum Levels of Zinc, Copper, Selenium and Glutathione Peroxidase in Different Groups of Colorectal Cancer Patients. Caspian J Intern Med. 2020; 11 (4) :385-392
URL: http://caspjim.com/article-1-2055-en.html


Volume 11, Issue 4 (6-2020) Back to browse issues page
Caspian Journal of Internal Medicine
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