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Evaluation the effect of Atorvastatin 1% mouthwash in prevention of radiotherapy induced mucositis: a pilot study
Shahram Ala , Majid Saeedi , Arash Ghasemi * , Melika Namdari , Neda Koulaeinejad
Department of radiology and radiation oncology, Faculty of medicine, Mazandaran University of medical science, Sari, Iran. , dr_arash_ghasemi@yahoo.com
Abstract:   (831 Views)
Background: Oral mucositis is a troublesome symptom for people who receive radiotherapy and chemotherapy and it is a dose-dependent factor. Atorvastatin is a HMG-CoA reductase inhibitors and various studies have proved its anti-inflammatory effects. The goal of this study is to evaluate atorvastatin 1% mouthwash effects in prevention of radiotherapy induced mucositis.
Methods: Atorvastatin 1% suspension was prepared for mouthwash in this randomized, double blind clinical trial. Thirty patients were randomly received atorvastatin or placebo mouthwash. They had to gargle 5cc of mouthwash, 3 times per day during radiotherapy. The severity and pain of mucositis was evaluated every week, during their treatment.
Results: The severity of mucositis between the two study groups was significant every four weeks (p < 0.05) and the percentage of patients with more severe mucositis was less in the atorvastatin group. It is found that the pain intensity was lower after 3 and 4 weeks, in atorvastatin group.
Conclusion: These findings indicated that atorvastatin mouthwash showed a significant activity in relieving of radiotherapy induced oral mucositis and pain.
Keywords: Atorvastatin, Mouthwash, Oral mucositis, Radiotherapy
     
Type of Study: Short Communication | Subject: Oncology
Received: 2021/03/13 | Accepted: 2021/09/18
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Caspian Journal of Internal Medicine
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