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:: Volume 2, Issue 3 (1-2011) ::
Caspian J Intern Med 2011, 2(3): 270-273 Back to browse issues page
Comparison of parenteral promethazine versus midazolam effect as a preoperative medication on postoperative nausea and vomiting after appendectomy
Nasrin Shirdashtzadeh *, Nazanin Eshraghi, Azadeh Eshraghi
Abstract:   (13197 Views)
Background: Postoperative nausea and vomiting is a high unpleasant symptom in surgical procedures. This study compares the effectiveness of midazolam with promethazine as multipurpose drug in postoperative nausea and vomiting as a preoperative and anesthetic medication after appendectomy.
Methods: This randomized, double – blind clinical trial study was performed in patients who underwent appendectomy. These patients randomly received either placebo or midazolam or promethazine 5 minutes before appendectomy. All episodes of vomiting and nausea within 24 hours after surgery were recorded. The study population (N=75) comprised 3 comparable subgroups (N=25 in each group). A standard general anesthetic technique and postoperative analgesia were used. The data were collected and analyzed.
Results: Vomiting and nausea occurred in 19.20%, 0% and 81.80% of the patients in the midazolam, promethazine and placebo groups, respectively. The frequency of postoperative nausea and vomiting was as follows: the first 6 hours after surgery 0%, 0% and 50%, during the second 6 hours after surgery 19%, 0% and 19%, during the third 6 hours after surgery 0%, 0% and 7%, during the fourth 6 hours after surgery 0%, 0% and 4% in the midazolam, promethazine and placebo groups, respectively. There were no significant differences between promethazine with midazolam in reduction of postoperative nausea and vomiting.
Conclusion: Our study suggests that midazolam can be used as multipurpose drugs in postoperative nausea and vomiting as a preoperative medication after appendectomy and treatment using midazolam for anti-emetic, prophylaxis provide a similar effect compared to promethazine in the present study.
Keywords: Midazolam, Postoperative nausea have vomiting, Promethazine
Full-Text [PDF 87 kb]   (1776 Downloads)    
Type of Study: Original Article | Subject: Infectious Diseases
Received: 2014/01/15 | Accepted: 2014/01/15 | Published: 2014/01/15
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Shirdashtzadeh N, Eshraghi N, Eshraghi A. Comparison of parenteral promethazine versus midazolam effect as a preoperative medication on postoperative nausea and vomiting after appendectomy. Caspian J Intern Med. 2011; 2 (3) :270-273
URL: http://caspjim.com/article-1-119-en.html


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Volume 2, Issue 3 (1-2011) Back to browse issues page
Caspian Journal of Internal Medicine
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