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:: Volume 10, Issue 4 (9-2019) ::
Caspian J Intern Med 2019, 10(4): 463-467 Back to browse issues page
Bradycardia Caused by interaction of Venlafaxine and Cyclosporine: A case report
Marzieh Azizi , Forouzan Elyasi * , Fatemeh Niksolat Roodposhti
Department of Psychiatry, Psychiatry and Behavioral Sciences Research Center and addiction Institute, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran , Forouzan. El @gmail.com
Abstract:   (2882 Views)
Background: Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are prescribed widely for the treatment of depression, anxiety disorders and other psychiatric disorders. Although antidepressants are considered as a safety drug category but unexpected cardiovascular events have been reported as the most serious complications. The aim of this study was to introduce a case presentation on bradycardia due to the drug interference of venlafaxine and cyclosporine.
Case presentation: The patient was a 38-year old woman diagnosed with systemic lupus erythematosus 5 years ago, who was admitted to a general educational hospital in northern Iran due to intensified rheumatologic symptoms and complaining about abdominal pain. Cyclosporine tab were administered to the patient, 50 mg twice daily. Two weeks after the administration of cyclosporine, the level of blood cyclosporine was checked. The patient became bradycardic after starting a single dose of venlafaxine (heart rate 52 ppm). Cardiac assessment showed no reason for bradycardia and it subsided after a drop of venlafaxine.
Conclusion: As a result of the potential adverse drug interactions between cyclosporine and antidepressants such as venlafaxine, physicians should be aware of the possibility of bradycardia in the simultaneous prescription of these drugs in cases.

Keywords: Bradycardia, Venlafaxine, Cyclosporine, Serotonin-Norepinephrine reuptake inhibitors, Selective serotonin reuptake inhibitors.
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Type of Study: case report | Subject: psychiatry
Received: 2017/12/15 | Accepted: 2019/02/20 | Published: 2019/09/25
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Azizi M, Elyasi F, Niksolat Roodposhti F. Bradycardia Caused by interaction of Venlafaxine and Cyclosporine: A case report. Caspian J Intern Med. 2019; 10 (4) :463-467
URL: http://caspjim.com/article-1-1321-en.html

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Volume 10, Issue 4 (9-2019) Back to browse issues page
Caspian Journal of Internal Medicine
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